You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SIGLEC7
Sialic acid-binding Ig-like lectin 7

Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305628
  • ENSP00000306757
  • ENSG00000168995
  • ENST00000317643
  • ENSP00000323328
  • ENST00000536156
  • ENSP00000437609
  • ENST00000600577
  • ENSP00000472529

Symbol
  • AIRM1
  • p75
  • QA79
  • AIRM1
  • CD328
  • CDw328
  • D-siglec
  • SIGLEC-7
  • SIGLECP2
  • SIGLEC19P
  • p75/AIRM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.65
kinase perturbation
0.54
small molecule perturbation
0.53
disease perturbation
0.49


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.45   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 749   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.45   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 749   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (65)
IFT74
Tbio
Novelty:  0.07195266
p_int:  0.999998414
p_ni:  0.000001116
p_wrong:  4.7e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
WDR89
Tdark
Novelty:  1.32691886
p_int:  0.994604217
p_ni:  0.004955784
p_wrong:  0.00044
Score:  0.379
Data Source:  BioPlex,STRINGDB
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.750075331
p_ni:  0.249924636
p_wrong:  3.3e-8
Score:  0.198
Data Source:  BioPlex,STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.699
Data Source:  STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.658
Data Source:  STRINGDB
KLK14
Tchem
Family:  Enzyme
Novelty:  0.02007434
Score:  0.648
Data Source:  STRINGDB
CD300A
Tbio
Novelty:  0.01745189
Score:  0.636
Data Source:  STRINGDB
LILRA1
Tdark
Novelty:  0.17371827
Score:  0.632
Data Source:  STRINGDB
SIGLEC15
Tbio
Novelty:  0.04928596
Score:  0.626
Data Source:  STRINGDB
LILRB1
Tbio
Novelty:  0.00463824
Score:  0.595
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
85.4
leukocyte count
2
2
2
84.4
myeloid white cell count
1
1
1
83.1
platelet crit
2
2
2
82.7
C-reactive protein measurement
1
2
2
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
85.4
leukocyte count
2
84.4
myeloid white cell count
1
83.1
platelet crit
2
82.7
C-reactive protein measurement
2
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 78.45
PubMed score by year
PubTator Score 63.99
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title