Tbio SIGLEC6 Sialic acid-binding Ig-like lectin 6

Protein Summary

Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• O43699
• A8MV71
• B2RTS8
• C9JBE5
• F8WA78
• O15388
• O43700
• Siglec-6

Gene Name

• SIGLEC6

Ensembl ID

• ENST00000343300
• ENSP00000345907
• ENSG00000105492
• ENST00000346477
• ENSP00000344064
• ENST00000359982
• ENSP00000353071
• ENST00000391797
• ENSP00000375674
• ENST00000425629
• ENSP00000401502
• ENST00000436458
• ENSP00000410679

Symbol

• CD33L
• CD33L1
• OBBP1
• CD327
• CD33L
• OBBP1
• CD33L1
• CD33L2
• CDW327

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
cell type or tissue	0.73
cell line	0.5
disease perturbation	0.49
small molecule perturbation	0.47

Protein Classes

PANTHER Classes

Protein / Structural Protein / Myelin Protein / Sialic Acid-binding Ig-like Lectin 6

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Sialic Acid-binding Ig-like Lectin 6

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 6

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 6

Protein / Cell Adhesion Molecule / Immunoglobulin Superfamily Cell Adhesion Molecule / Sialic Acid-binding Ig-like Lectin 6

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 350   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0