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Tbio
SIGLEC15
Sialic acid-binding Ig-like lectin 15

Protein Summary
Description
Binds sialylated glycoproteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389474
  • ENSP00000374125
  • ENSG00000197046
  • ENST00000546268
  • ENSP00000443509

Symbol
  • CD33L3
  • CD33L3
  • HsT1361
  • SIGLEC-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.64
gene perturbation
0.61
protein domain
0.58
cell line
0.48
small molecule perturbation
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.954
Data Source:  Reactome,STRINGDB
CD22
Tclin
Novelty:  0.0009372
Score:  0.835
Data Source:  STRINGDB
SIGLEC1
Tbio
Novelty:  0.00369952
Score:  0.824
Data Source:  STRINGDB
MAG
Tchem
Novelty:  0.00085621
Score:  0.75
Data Source:  STRINGDB
CD300LB
Tbio
Novelty:  0.10587821
Score:  0.64
Data Source:  STRINGDB
SIGLEC7
Tchem
Novelty:  0.01496432
Score:  0.626
Data Source:  STRINGDB
ST3GAL2
Tbio
Family:  Enzyme
Novelty:  0.03503891
Score:  0.586
Data Source:  STRINGDB
SIGLEC11
Tbio
Novelty:  0.07703071
Score:  0.566
Data Source:  STRINGDB
HCST
Tbio
Novelty:  0.01604587
Score:  0.534
Data Source:  STRINGDB
SIGLEC9
Tbio
Novelty:  0.01805735
Score:  0.526
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
DAP12 interactions (R-HSA-2172127)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DAP12 interactions
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
92.7
reticulocyte count
1
1
1
69.5
reticulocyte measurement
1
1
1
66.3
2
2
0
1.2
57.7
hematocrit
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
92.7
reticulocyte count
1
69.5
reticulocyte measurement
1
66.3
0
1.2
57.7
hematocrit
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 15
VGNC:5205
455394
Macaque
sialic acid binding Ig like lectin 15
700656
Mouse
MGI:3646642
620235
Rat
RGD:1565948
498888
Dog
sialic acid binding Ig like lectin 15
VGNC:46169
100855945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 15
Macaque
sialic acid binding Ig like lectin 15
Mouse
Rat
Dog
sialic acid binding Ig like lectin 15
Publication Statistics
PubMed Score 34.76
PubMed score by year
PubTator Score 2.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title