Tbio SIGLEC12 Sialic acid-binding Ig-like lectin 12

Protein Summary

Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q96PQ1
• Q8IYH7
• Siglec-12

Gene Name

• SIGLEC12

Ensembl ID

• ENST00000291707
• ENSP00000291707
• ENSG00000254521
• ENST00000598614
• ENSP00000472873

Symbol

• SIGLECL1
• SLG
• S2V
• SLG
• SIGLECL1
• Siglec-XII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
cell line	0.71
cell type or tissue	0.58
tissue	0.37
biological term	0.34

Protein Classes

PANTHER Classes

Protein / Structural Protein / Myelin Protein / Sialic Acid-binding Ig-like Lectin 12

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Sialic Acid-binding Ig-like Lectin 12

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 12

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 12

Protein / Cell Adhesion Molecule / Immunoglobulin Superfamily Cell Adhesion Molecule / Sialic Acid-binding Ig-like Lectin 12

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.21   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.21   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0