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Tbio
SIGLEC10
Sialic acid-binding Ig-like lectin 10

Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339313
  • ENSP00000345243
  • ENSG00000142512
  • ENST00000353836
  • ENSP00000342389
  • ENST00000436984
  • ENSP00000414324
  • ENST00000439889
  • ENSP00000389132
  • ENST00000441969
  • ENSP00000408387
  • ENST00000442846
  • ENSP00000395475

Symbol
  • SLG2
  • SLG2
  • PRO940
  • SIGLEC-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.65
kinase
0.62
tissue
0.62
cell line
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
SIGLEC16
Tdark
p_int:  1
Data Source:  BioPlex
CD72
Tbio
Novelty:  0.00787437
p_int:  0.999682598
p_ni:  0.000317388
p_wrong:  1.4e-8
Score:  0.608
Data Source:  BioPlex,STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
p_int:  0.993513533
p_ni:  0.006486467
Score:  0.345
Data Source:  BioPlex,STRINGDB
PTRH2
Tbio
Family:  Enzyme
Novelty:  0.02494576
p_int:  0.884587146
p_ni:  0.115325508
p_wrong:  0.000087345
Score:  0.157
Data Source:  BioPlex,STRINGDB
TMEM132A
Tbio
Novelty:  0.26489093
p_int:  0.878006167
p_ni:  0.121992039
p_wrong:  0.000001795
Score:  0.157
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.811748342
p_ni:  0.188251658
Data Source:  BioPlex
CD24
Tbio
Novelty:  0.00097222
Score:  0.715
Data Source:  STRINGDB
HMGB1
Tchem
Family:  TF
Novelty:  0.00043845
Score:  0.647
Data Source:  STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
Score:  0.518
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.499
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
47.6
body mass index
2
2
2
46.9
blood protein measurement
1
1
1
39.5
lymphocyte percentage of leukocytes
1
1
1
22.8
1
1
0
1.8
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
47.6
body mass index
2
46.9
blood protein measurement
1
39.5
lymphocyte percentage of leukocytes
1
22.8
0
1.8
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 10
VGNC:2426
468977
Macaque
sialic acid binding Ig like lectin 10
719648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 10
Macaque
sialic acid binding Ig like lectin 10
Publication Statistics
PubMed Score 42.01
PubMed score by year
PubTator Score 17.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title