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Tbio
SIGLEC1
Sialoadhesin

Protein Summary
Description
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344754
  • ENSP00000341141
  • ENSG00000088827

Symbol
  • SN
  • SN
  • CD169
  • SIGLEC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
virus perturbation
0.83
tissue sample
0.59
microRNA
0.55
phenotype
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.32   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 610   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.32   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 610   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
SPN
Tbio
Novelty:  0.00121061
Score:  0.937
Data Source:  STRINGDB
SIGLEC15
Tbio
Novelty:  0.04928596
Score:  0.824
Data Source:  STRINGDB
CD163
Tbio
Novelty:  0.0007415
Score:  0.777
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.752
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.731
Data Source:  STRINGDB
MRC1
Tbio
Novelty:  0.00104675
Score:  0.73
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.704
Data Source:  STRINGDB
PASK
Tchem
Family:  Kinase
Novelty:  0.14004084
Score:  0.675
Data Source:  STRINGDB
CLEC10A
Tbio
Novelty:  0.00656565
Score:  0.673
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.664
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
6
6
96.9
reticulocyte count
5
5
7
92.4
mean corpuscular volume
1
2
2
91.7
reticulocyte measurement
2
2
3
88.4
mean reticulocyte volume
1
2
2
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
6
96.9
reticulocyte count
7
92.4
mean corpuscular volume
2
91.7
reticulocyte measurement
3
88.4
mean reticulocyte volume
2
77.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 1
VGNC:9977
469866
Macaque
sialic acid binding Ig like lectin 1
717470
Mouse
MGI:99668
20612
Rat
RGD:1311953
311426
Dog
sialic acid binding Ig like lectin 1
VGNC:46168
485794
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 1
Macaque
sialic acid binding Ig like lectin 1
Mouse
Rat
Dog
sialic acid binding Ig like lectin 1
Publication Statistics
PubMed Score 314.32
PubMed score by year
PubTator Score 116.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title