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Tbio
SIDT2
SID1 transmembrane family member 2

Protein Summary
Description
Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324225
  • ENSP00000314023
  • ENSG00000149577
  • ENST00000620360
  • ENSP00000482762

Symbol
  • CGI-40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.93
kinase perturbation
0.84
histone modification site profile
0.74
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.39   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.39   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
TM2D2
Tdark
Novelty:  0.10390283
p_int:  0.999811881
p_ni:  0.000188108
p_wrong:  1.1e-8
Data Source:  BioPlex
PTH1R
Tclin
Family:  GPCR
Novelty:  0.00413989
p_int:  0.999424469
p_ni:  0.00057532
p_wrong:  2.12e-7
Data Source:  BioPlex
KLRC4
Tbio
Novelty:  0.16922525
p_int:  0.999330355
p_ni:  0.000669151
p_wrong:  4.94e-7
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.999311733
p_ni:  0.000687992
p_wrong:  2.75e-7
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.999257291
p_ni:  0.000742706
p_wrong:  3e-9
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.998141318
p_ni:  0.00185867
p_wrong:  1.2e-8
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.995629025
p_ni:  0.003315038
p_wrong:  0.001055937
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.994712766
p_ni:  0.005286978
p_wrong:  2.56e-7
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.994089413
p_ni:  0.005513983
p_wrong:  0.000396604
Score:  0.164
Data Source:  BioPlex,STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.992775046
p_ni:  0.006919926
p_wrong:  0.000305028
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
12
19
99.8
high density lipoprotein cholesterol measurement
7
9
11
17
99
apolipoprotein A 1 measurement
2
7
7
98.8
total cholesterol measurement
2
4
5
93.8
apolipoprotein B measurement
2
4
4
90.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
19
99.8
high density lipoprotein cholesterol measurement
11
17
99
apolipoprotein A 1 measurement
7
98.8
total cholesterol measurement
5
93.8
apolipoprotein B measurement
4
90.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SID1 transmembrane family member 2
VGNC:3051
451569
Macaque
SID1 transmembrane family member 2
697321
Mouse
MGI:2446134
214597
Rat
RGD:1308311
315617
Dog
SID1 transmembrane family member 2
VGNC:46166
100856519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SID1 transmembrane family member 2
Macaque
SID1 transmembrane family member 2
Mouse
Rat
Dog
SID1 transmembrane family member 2
Publication Statistics
PubMed Score 20.39
PubMed score by year
PubTator Score 5.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title