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Tbio
SIAE
Sialate O-acetylesterase

Protein Summary
Description
Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263593
  • ENSP00000263593
  • ENSG00000110013
  • ENST00000545756
  • ENSP00000437877
  • ENST00000618733
  • ENSP00000478211

Symbol
  • YSG2
  • LSE
  • AIS6
  • CSEC
  • YSG2
  • CSE-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.84
cell type or tissue
0.67
cell line
0.63
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.66   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.66   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.999669874
p_ni:  0.000330126
Score:  0.75
Data Source:  BioPlex,STRINGDB
COL18A1
Tbio
Novelty:  0.00074602
p_int:  0.997863846
p_ni:  0.002136154
Data Source:  BioPlex
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.997581287
p_ni:  0.002418713
Score:  0.185
Data Source:  BioPlex,STRINGDB
PLTP
Tbio
Novelty:  0.00267612
p_int:  0.996188972
p_ni:  0.003810909
p_wrong:  1.2e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
GDF11
Tclin
Novelty:  0.00585981
p_int:  0.996085108
p_ni:  0.003914888
p_wrong:  4e-9
Data Source:  BioPlex
MANEAL
Tdark
Family:  Enzyme
Novelty:  0.71535497
p_int:  0.995237757
p_ni:  0.004526256
p_wrong:  0.000235987
Score:  0.185
Data Source:  BioPlex,STRINGDB
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
p_int:  0.994142899
p_ni:  0.005839606
p_wrong:  0.000017495
Data Source:  BioPlex
OAF
Tbio
Novelty:  0.07130797
p_int:  0.992202079
p_ni:  0.007797912
p_wrong:  9e-9
Data Source:  BioPlex
DCBLD2
Tbio
Novelty:  0.06514947
p_int:  0.991698582
p_ni:  0.007550401
p_wrong:  0.000751017
Score:  0.545
Data Source:  BioPlex,STRINGDB
TENM3
Tbio
Novelty:  0.0251948
p_int:  0.989441231
p_ni:  0.009188357
p_wrong:  0.001370412
Score:  0.286
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
60.2
8
2
2
1.1
59.5
1
1
0
1.1
56.8
self reported educational attainment
1
1
1
40.7
intelligence
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
60.2
2
1.1
59.5
0
1.1
56.8
self reported educational attainment
1
40.7
intelligence
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sialic acid acetylesterase
VGNC:1006
451636
Macaque
sialic acid acetylesterase
711816
Mouse
MGI:104803
22619
Rat
RGD:1310431
363045
Dog
sialic acid acetylesterase
VGNC:46162
489311
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sialic acid acetylesterase
Macaque
sialic acid acetylesterase
Mouse
Rat
Dog
sialic acid acetylesterase
Publication Statistics
PubMed Score 95.66
PubMed score by year
PubTator Score 51.56
PubTator score by year
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Related Publications
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PMID
Year
Title