Tbio SHTN1 Shootin-1

Protein Summary

Description

Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.

Uniprot Accession IDs

• A0MZ66
• A8MYU7
• B3KRD3
• B3KRH2
• B3KTE0
• B3KTJ7
• B3KTJ8
• B4E3U1
• B7Z7Z9
• Q68DG1
• Q6PIM5
• Q9HCH4
• Q9NUV0

Gene Name

• SHTN1

Ensembl ID

• ENST00000260777
• ENSP00000260777
• ENSG00000187164
• ENST00000355371
• ENSP00000347532
• ENST00000392901
• ENSP00000376635
• ENST00000392903
• ENSP00000376636
• ENST00000615301
• ENSP00000480109

Symbol

• KIAA1598
• KIAA1598
• shootin-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

• See Interactions on String-DB

RNF41

Tbio

Family:  Enzyme

Novelty:  0.01953473

p_int:  0.999999856

p_ni:  3.7e-8

p_wrong:  1.06e-7

Data Source:  BioPlex

LURAP1L

Tdark

Novelty:  2.32630524

p_int:  0.999996307

p_ni:  0.000003689

p_wrong:  4e-9

Score:  0.516

Data Source:  BioPlex,STRINGDB

FAM167A

Tbio

Novelty:  0.05232679

p_int:  0.999990142

p_ni:  0.000009858

Data Source:  BioPlex

BCHE

Tclin

Family:  Enzyme

Novelty:  0.00031267

p_int:  0.99976861

p_ni:  0.000231385

p_wrong:  4e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

NDEL1

Tbio

Novelty:  0.01241819

p_int:  0.99881887

p_ni:  0.001177041

p_wrong:  0.000004089

Score:  0.214

Data Source:  BioPlex,STRINGDB

TEX30

Tdark

Novelty:  0.69754742

p_int:  0.998519829

p_ni:  0.001480169

p_wrong:  3e-9

Data Source:  BioPlex

ZCCHC17

Tbio

Novelty:  0.06999007

p_int:  0.998499935

p_ni:  0.001499219

p_wrong:  8.45e-7

Score:  0.184

Data Source:  BioPlex,STRINGDB

FAM24B

Tdark

Novelty:  1.04675689

p_int:  0.926250056

p_ni:  0.068177957

p_wrong:  0.005571987

Data Source:  BioPlex

CAV3

Tbio

Novelty:  0.00190092

p_int:  0.893475812

p_ni:  0.106185173

p_wrong:  0.000339015

Score:  0.185

Data Source:  BioPlex,STRINGDB

L1CAM

Tbio

Novelty:  0.00307041

Score:  0.945

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Axon guidance (R-HSA-422475)

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	L1CAM interactions	100 targets	R-HSA-373760
Reactome	Recycling pathway of L1	28 targets	R-HSA-437239

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
L1CAM interactions	100 targets	R-HSA-373760
Recycling pathway of L1	28 targets	R-HSA-437239

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (3)

Components (12)

Processes (12)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
actin filament binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
kinesin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	1	2	0	15.9	80.3
cleft lip	EFO_0003959	7	4	1	1.3	74.3
Cleft palate	HP_0000175	3	3	0	1.3	72.3
cup-to-disc ratio measurement	EFO_0006939	3	2	3		69.6
body mass index	EFO_0004340	3	1	3		63.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	0	15.9	80.3
cleft lip	EFO_0003959	1	1.3	74.3
Cleft palate	HP_0000175	0	1.3	72.3
cup-to-disc ratio measurement	EFO_0006939	3		69.6
body mass index	EFO_0004340	3		63.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Developmental protein
Direct protein sequencing
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
age at first birth measurement
age at first sexual intercourse measurement
body fat percentage
body height
body mass index
C-reactive protein measurement
cleft lip
Cleft palate
cortical surface area measurement
cup-to-disc ratio measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	shootin 1	VGNC:5730	466211
Macaque	shootin 1		700636
Mouse	shootin 1	MGI:1918903	71653
Dog	shootin 1	VGNC:46160	486905
Horse	shootin 1	VGNC:22969	100067493

Species	Name	OMA	EggNOG	Inparanoid
Chimp	shootin 1
Macaque	shootin 1
Mouse	shootin 1
Dog	shootin 1
Horse	shootin 1

Publication Statistics

PubMed Score 18.53

PubMed score by year

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PubTator Score 8.95

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title