Protein Summary
Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
- ENST00000260777
- ENSP00000260777
- ENSG00000187164
- ENST00000355371
- ENSP00000347532
- ENST00000392901
- ENSP00000376635
- ENST00000392903
- ENSP00000376636
- ENST00000615301
- ENSP00000480109
- KIAA1598
- KIAA1598
- shootin-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.53 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 35 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.53 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 35 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (40)
RNF41
Family: Enzyme
Novelty: 0.01953473
p_int: 0.999999856
p_ni: 3.7e-8
p_wrong: 1.06e-7
Data Source: BioPlex
LURAP1L
Novelty: 2.32630524
p_int: 0.999996307
p_ni: 0.000003689
p_wrong: 4e-9
Score: 0.516
Data Source: BioPlex,STRINGDB
BCHE
Family: Enzyme
Novelty: 0.00031267
p_int: 0.99976861
p_ni: 0.000231385
p_wrong: 4e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
NDEL1
Novelty: 0.01241819
p_int: 0.99881887
p_ni: 0.001177041
p_wrong: 0.000004089
Score: 0.214
Data Source: BioPlex,STRINGDB
TEX30
Novelty: 0.69754742
p_int: 0.998519829
p_ni: 0.001480169
p_wrong: 3e-9
Data Source: BioPlex
ZCCHC17
Novelty: 0.06999007
p_int: 0.998499935
p_ni: 0.001499219
p_wrong: 8.45e-7
Score: 0.184
Data Source: BioPlex,STRINGDB
FAM24B
Novelty: 1.04675689
p_int: 0.926250056
p_ni: 0.068177957
p_wrong: 0.005571987
Data Source: BioPlex
CAV3
Novelty: 0.00190092
p_int: 0.893475812
p_ni: 0.106185173
p_wrong: 0.000339015
Score: 0.185
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | L1CAM interactions | ||||
Reactome | Recycling pathway of L1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
L1CAM interactions | ||||
Recycling pathway of L1 | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (3)
Components (12)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
cortical surface area measurement | 1 | 2 | 0 | 15.9 | 80.3 | ||||
7 | 4 | 1 | 1.3 | 74.3 | |||||
Cleft palate | 3 | 3 | 0 | 1.3 | 72.3 | ||||
cup-to-disc ratio measurement | 3 | 2 | 3 | 69.6 | |||||
body mass index | 3 | 1 | 3 | 63.7 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
cortical surface area measurement | 0 | 15.9 | 80.3 | ||||
1 | 1.3 | 74.3 | |||||
Cleft palate | 0 | 1.3 | 72.3 | ||||
cup-to-disc ratio measurement | 3 | 69.6 | |||||
body mass index | 3 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | shootin 1 | VGNC:5730 | 466211 | |||||
Macaque | shootin 1 | 700636 | ||||||
Mouse | MGI:1918903 | 71653 | ||||||
Dog | shootin 1 | VGNC:46160 | 486905 | |||||
Horse | shootin 1 | VGNC:22969 | 100067493 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | shootin 1 | |||||
Macaque | shootin 1 | |||||
Mouse | ||||||
Dog | shootin 1 | |||||
Horse | shootin 1 | |||||
Publication Statistics
PubMed Score 18.53
PubMed score by year
PubTator Score 8.95
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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