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Tbio
SHQ1
Protein SHQ1 homolog

Protein Summary
Description
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325599
  • ENSP00000315182
  • ENSG00000144736
  • ENST00000463369
  • ENSP00000417452

Symbol
  • Shq1p
  • GRIM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.78
kinase perturbation
0.76
tissue sample
0.56
cellular component
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.6   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.6   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
DKC1
Tbio
Novelty:  0.00352181
p_int:  0.999999921
p_ni:  7.3e-8
p_wrong:  6e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.99999344
p_ni:  0.00000656
p_wrong:  1e-9
Score:  0.68
Data Source:  BioPlex,STRINGDB
GAR1
Tbio
Novelty:  0.26091307
p_int:  0.999953997
p_ni:  0.000046001
p_wrong:  2e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.999708133
p_ni:  0.000285507
p_wrong:  0.00000636
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.99579658
p_ni:  0.004201944
p_wrong:  0.000001476
Score:  0.246
Data Source:  BioPlex,STRINGDB
KNOP1
Tdark
Novelty:  0.5609503
p_int:  0.976224963
p_ni:  0.020673383
p_wrong:  0.003101654
Score:  0.534
Data Source:  BioPlex,STRINGDB
NOP10
Tbio
Novelty:  0.0188462
Score:  0.974
Data Source:  STRINGDB
NHP2
Tbio
Novelty:  0.01414024
Score:  0.927
Data Source:  STRINGDB
TRUB1
Tbio
Family:  Enzyme
Novelty:  0.07013834
Score:  0.838
Data Source:  STRINGDB
NOP58
Tbio
Novelty:  0.02148045
Score:  0.78
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1.1
64.9
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
64.9
1
3.8
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SHQ1, H/ACA ribonucleoprotein assembly factor
VGNC:8854
460507
Macaque
SHQ1, H/ACA ribonucleoprotein assembly factor
693923
Mouse
MGI:1919421
72171
Rat
RGD:1310610
297483
Dog
SHQ1, H/ACA ribonucleoprotein assembly factor
VGNC:46155
476557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SHQ1, H/ACA ribonucleoprotein assembly factor
Macaque
SHQ1, H/ACA ribonucleoprotein assembly factor
Mouse
Rat
Dog
SHQ1, H/ACA ribonucleoprotein assembly factor
Publication Statistics
PubMed Score 11.60
PubMed score by year
PubTator Score 6.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title