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Tbio
SHPRH
E3 ubiquitin-protein ligase SHPRH

Protein Summary
Description
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275233
  • ENSP00000275233
  • ENSG00000146414
  • ENST00000367505
  • ENSP00000356475
  • ENST00000438092
  • ENSP00000412797
  • ENST00000519632
  • ENSP00000430528

Symbol
  • KIAA2023
  • bA545I5.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
histone modification site profile
0.79
cell type or tissue
0.63
transcription factor binding site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999998088
p_ni:  0.000001912
Score:  0.672
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.887843964
p_ni:  0.112156036
Score:  0.195
Data Source:  BioPlex,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.989
Data Source:  Reactome,STRINGDB
UBE2V2
Tbio
Novelty:  0.01112479
Score:  0.988
Data Source:  Reactome,STRINGDB
RAD18
Tbio
Family:  Enzyme
Novelty:  0.00519213
Score:  0.984
Data Source:  Reactome,STRINGDB
UBE2B
Tchem
Novelty:  0.01578275
Score:  0.97
Data Source:  Reactome,STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.952
Data Source:  Reactome,STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.911
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.911
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
52.9
appendicular lean mass
1
1
1
18.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
52.9
appendicular lean mass
1
18.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SNF2 histone linker PHD RING helicase
VGNC:8563
472146
Macaque
SNF2 histone linker PHD RING helicase
699114
Mouse
MGI:1917581
268281
Rat
RGD:1310342
308282
Dog
SNF2 histone linker PHD RING helicase
VGNC:49029
476233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SNF2 histone linker PHD RING helicase
Macaque
SNF2 histone linker PHD RING helicase
Mouse
Rat
Dog
SNF2 histone linker PHD RING helicase
Publication Statistics
PubMed Score 32.99
PubMed score by year
PubTator Score 8.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title