Protein Summary
Acts as a modulator of macrophage activation through control of glucose metabolism. The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
- ENST00000225519
- ENSP00000225519
- ENSG00000197417
- CARKL
- SHK
- CARKL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
molecular function | 0.88 | ||
transcription factor perturbation | 0.74 | ||
tissue sample | 0.73 | ||
transcription factor binding site profile | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.85 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.85 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
TRAF3
Novelty: 0.0022525
p_int: 0.999736063
p_ni: 0.000263869
p_wrong: 6.8e-8
Score: 0.243
Data Source: BioPlex,STRINGDB
TCF25
Novelty: 0.08961823
p_int: 0.988545725
p_ni: 0.011454275
Score: 0.209
Data Source: BioPlex,STRINGDB
NR2F2
Family: NR
Novelty: 0.00450561
p_int: 0.977278418
p_ni: 0.022721582
Score: 0.317
Data Source: BioPlex,STRINGDB
FAM126A
Novelty: 0.0250547
p_int: 0.965100916
p_ni: 0.034899084
Score: 0.817
Data Source: BioPlex,STRINGDB
THYN1
Novelty: 0.11624704
p_int: 0.958334692
p_ni: 0.041665308
Score: 0.29
Data Source: BioPlex,STRINGDB
LINC01587
Novelty: 0.48128342
p_int: 0.953443747
p_ni: 0.046556251
p_wrong: 2e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
GATD1
Family: Enzyme
Novelty: 0.40291197
p_int: 0.934535768
p_ni: 0.065464232
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Reactome | Pentose phosphate pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of carbohydrates | ||||
Pentose phosphate pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (2)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | sedoheptulokinase | 721465 | ||||||
Mouse | MGI:1921887 | 74637 | ||||||
Rat | RGD:1308004 | 287479 | ||||||
Dog | sedoheptulokinase | 491219 | ||||||
Pig | sedoheptulokinase | 100515408 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | sedoheptulokinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | sedoheptulokinase | |||||
Pig | sedoheptulokinase | |||||
Publication Statistics
PubMed Score 5.85
PubMed score by year
PubTator Score 11.95
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (4)
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