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Tbio
SHPK
Sedoheptulokinase

Protein Summary
Description
Acts as a modulator of macrophage activation through control of glucose metabolism. The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225519
  • ENSP00000225519
  • ENSG00000197417

Symbol
  • CARKL
  • SHK
  • CARKL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
molecular function
0.88
transcription factor perturbation
0.74
tissue sample
0.73
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
MCOLN2
Tchem
Family:  IC
Novelty:  0.05195244
p_int:  0.99988748
p_ni:  0.00011252
Data Source:  BioPlex
TRAF3
Tbio
Novelty:  0.0022525
p_int:  0.999736063
p_ni:  0.000263869
p_wrong:  6.8e-8
Score:  0.243
Data Source:  BioPlex,STRINGDB
TCF25
Tbio
Novelty:  0.08961823
p_int:  0.988545725
p_ni:  0.011454275
Score:  0.209
Data Source:  BioPlex,STRINGDB
NR2F2
Tchem
Family:  NR
Novelty:  0.00450561
p_int:  0.977278418
p_ni:  0.022721582
Score:  0.317
Data Source:  BioPlex,STRINGDB
FAM126A
Tbio
Novelty:  0.0250547
p_int:  0.965100916
p_ni:  0.034899084
Score:  0.817
Data Source:  BioPlex,STRINGDB
THYN1
Tbio
Novelty:  0.11624704
p_int:  0.958334692
p_ni:  0.041665308
Score:  0.29
Data Source:  BioPlex,STRINGDB
LINC01587
Tdark
Novelty:  0.48128342
p_int:  0.953443747
p_ni:  0.046556251
p_wrong:  2e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
p_int:  0.934535768
p_ni:  0.065464232
Data Source:  BioPlex
CTNS
Tbio
Novelty:  0.00448623
Score:  0.906
Data Source:  STRINGDB
ASPA
Tbio
Family:  Enzyme
Novelty:  0.02701619
Score:  0.796
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sedoheptulokinase
721465
Mouse
MGI:1921887
74637
Rat
RGD:1308004
287479
Dog
sedoheptulokinase
491219
Pig
sedoheptulokinase
100515408
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sedoheptulokinase
Mouse
Rat
Dog
sedoheptulokinase
Pig
sedoheptulokinase
Publication Statistics
PubMed Score 5.85
PubMed score by year
PubTator Score 11.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title