Tbio SHOC2 Leucine-rich repeat protein SHOC-2

Protein Summary

Description

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9UQ13
• A8K9W8
• B3KR23
• O76063
• Q5VZS8
• Q5VZS9

Gene Name

• SHOC2

Ensembl ID

• ENST00000265277
• ENSP00000265277
• ENSG00000108061
• ENST00000369452
• ENSP00000358464

Symbol

• KIAA0862
• SOC2
• SUR8
• SIAA0862

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.94
disease perturbation	0.93
transcription factor binding site profile	0.86
histone modification site profile	0.81
microRNA	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.2   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.2   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (105)

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1 – 10 of 105

• See Interactions on String-DB

PPP1CA

Tchem

Family:  Enzyme

Novelty:  0.00354658

p_int:  0.999999989

p_ni:  1e-9

p_wrong:  1e-8

Score:  0.968

Data Source:  BioPlex,STRINGDB

PPP1CC

Tchem

Family:  Enzyme

Novelty:  0.00465946

p_int:  0.999999984

p_ni:  1.3e-8

p_wrong:  3e-9

Score:  0.987

Data Source:  BioPlex,STRINGDB

ALDOB

Tbio

Family:  Enzyme

Novelty:  0.00856695

p_int:  0.999635852

p_ni:  0.000057263

p_wrong:  0.000306885

Data Source:  BioPlex

HRAS

Tchem

Family:  Enzyme

Novelty:  0.00008069

Score:  0.976

Data Source:  STRINGDB

KRAS

Tclin

Family:  Enzyme

Novelty:  0.00013856

Score:  0.972

Data Source:  STRINGDB

RAF1

Tclin

Family:  Kinase

Novelty:  0.00117121

Score:  0.968

Data Source:  STRINGDB

NRAS

Tchem

Family:  Enzyme

Novelty:  0.00080922

Score:  0.962

Data Source:  STRINGDB

MRAS

Tbio

Family:  Enzyme

Novelty:  0.01544981

Score:  0.962

Data Source:  STRINGDB

PPP1CB

Tbio

Family:  Enzyme

Novelty:  0.0122614

Score:  0.947

Data Source:  STRINGDB

PPP2R2A

Tchem

Family:  Enzyme

Novelty:  0.01723628

Score:  0.939

Data Source:  STRINGDB

Nearest Tclin Targets (1)

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Downstream (1)

1 – 1 of 1

RAF1

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Ras signaling pathway

Pathways (3)

KEGG (1)

WikiPathways (2)

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Ras signaling pathway	230 targets	path:hsa04014

Name	Explore in Pharos	Explore in Source
Ras signaling pathway	230 targets	path:hsa04014

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (7)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
protein phosphatase 1 binding	Inferred from Direct Assay (IDA)	UniProtKB
protein phosphatase binding	Inferred from Direct Assay (IDA)	UniProtKB
protein serine/threonine phosphatase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein phosphatase regulator activity	Traceable Author Statement (TAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	3	2	2	1.1	71.1
diet measurement	EFO_0008111	1	2	2		46.8
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		4.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	2	1.1	71.1
diet measurement	EFO_0008111	2		46.8
neutrophil percentage of leukocytes	EFO_0007990	1		4.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Leucine-rich repeat
Nucleus
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
diet measurement
neutrophil percentage of leukocytes
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SHOC2, leucine rich repeat scaffold protein	VGNC:12500	466200
Macaque	SHOC2, leucine rich repeat scaffold protein		695572
Mouse	soc-2 (suppressor of clear) homolog (C. elegans)	MGI:1927197	56392
Rat	SHOC2 leucine-rich repeat scaffold protein	RGD:1308146	309548
Dog	SHOC2, leucine rich repeat scaffold protein	VGNC:46152	477819

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SHOC2, leucine rich repeat scaffold protein
Macaque	SHOC2, leucine rich repeat scaffold protein
Mouse	soc-2 (suppressor of clear) homolog (C. elegans)
Rat	SHOC2 leucine-rich repeat scaffold protein
Dog	SHOC2, leucine rich repeat scaffold protein

Publication Statistics

PubMed Score 90.20

PubMed score by year

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PubTator Score 47.90

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (19)

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PMID	Year	Title