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Tbio
SHLD2
Shieldin complex subunit 2

Protein Summary
Description
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298784
  • ENSP00000298784
  • ENSG00000122376
  • ENST00000298786
  • ENSP00000298786

Symbol
  • FAM35A
  • RINN2
  • RINN2
  • FAM35A
  • FAM35A1
  • bA163M19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
kinase perturbation
0.71
tissue sample
0.71
cellular component
0.57
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.99999881
p_ni:  9.3e-8
p_wrong:  0.000001097
Score:  0.187
Data Source:  BioPlex,STRINGDB
SHLD3
Tbio
Novelty:  1.98567335
Score:  0.873
Data Source:  STRINGDB
SHLD1
Tbio
Novelty:  1.03046307
Score:  0.827
Data Source:  STRINGDB
MAD2L2
Tbio
Novelty:  0.01091072
Score:  0.729
Data Source:  STRINGDB
NIPAL1
Tdark
Novelty:  0.30221354
Score:  0.669
Data Source:  STRINGDB
CNIH2
Tbio
Novelty:  0.08676822
Score:  0.558
Data Source:  STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
Score:  0.45
Data Source:  STRINGDB
CUX2
Tbio
Family:  TF
Novelty:  0.02004476
Score:  0.426
Data Source:  STRINGDB
RFX3
Tbio
Family:  TF
Novelty:  0.04646733
Score:  0.418
Data Source:  STRINGDB
BCAS3
Tbio
Novelty:  0.0343539
Score:  0.418
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
3
4
86.8
5
4
0
1.4
86
hemoglobin measurement
2
2
2
75.7
hematocrit
2
2
2
66.6
red blood cell density measurement
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
86.8
0
1.4
86
hemoglobin measurement
2
75.7
hematocrit
2
66.6
red blood cell density measurement
1
63.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
shieldin complex subunit 2
VGNC:12329
450578
Macaque
family with sequence similarity 35 member A
694102
Mouse
MGI:1922948
75698
Dog
shieldin complex subunit 2
VGNC:40677
100683609
Horse
shieldin complex subunit 2
VGNC:17869
100064114
Species
Name
OMA
EggNOG
Inparanoid
Chimp
shieldin complex subunit 2
Macaque
family with sequence similarity 35 member A
Mouse
Dog
shieldin complex subunit 2
Horse
shieldin complex subunit 2
Publication Statistics
PubMed Score 3.34
PubMed score by year
PubTator Score 2.06
PubTator score by year
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Related Publications
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PMID
Year
Title