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Tbio
SHKBP1
SH3KBP1-binding protein 1

Protein Summary
Description
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291842
  • ENSP00000291842
  • ENSG00000160410

Symbol
  • SB1
  • Sb1
  • PP203
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.77
tissue
0.71
cell line
0.67
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.24   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.24   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
KCTD3
Tdark
Novelty:  0.33599775
p_int:  0.999999983
p_ni:  1.8e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.999999633
p_ni:  3.67e-7
Data Source:  BioPlex
PDZK1P1
Tdark
p_int:  0.999999204
p_ni:  7.96e-7
Data Source:  BioPlex
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.999987881
p_ni:  0.000012119
Score:  0.204
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999952302
p_ni:  0.000047698
Data Source:  BioPlex
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.999944707
p_ni:  0.000055293
Score:  0.667
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999889786
p_ni:  0.000110214
Data Source:  BioPlex
TNFAIP3
Tbio
Novelty:  0.00257088
p_int:  0.999502219
p_ni:  0.000497781
Score:  0.525
Data Source:  BioPlex,STRINGDB
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.973159832
p_ni:  0.026840168
Score:  0.173
Data Source:  BioPlex,STRINGDB
TENT5A
Tbio
Novelty:  0.08412895
p_int:  0.972965527
p_ni:  0.027034473
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
2
2
92.7
appendicular lean mass
1
1
1
57.8
hematocrit
1
1
1
56.8
hemoglobin measurement
1
1
1
47.7
eosinophil count
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
92.7
appendicular lean mass
1
57.8
hematocrit
1
56.8
hemoglobin measurement
1
47.7
eosinophil count
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3KBP1 binding protein 1
VGNC:2249
456041
Macaque
SH3KBP1 binding protein 1
703146
Mouse
MGI:2385803
192192
Rat
RGD:1309281
292735
Dog
SH3KBP1 binding protein 1
VGNC:46149
476455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3KBP1 binding protein 1
Macaque
SH3KBP1 binding protein 1
Mouse
Rat
Dog
SH3KBP1 binding protein 1
Publication Statistics
PubMed Score 425.24
PubMed score by year
PubTator Score 84.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title