Protein Summary
Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). Sonic hedgehog protein N-product: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in a ...more
- ENST00000297261
- ENSP00000297261
- ENSG00000164690
- TPT
- HHG1
- HLP3
- HPE3
- SMMCI
- ShhNC
- TPTPS
- MCOPCB5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
protein domain | 0.97 | ||
phenotype | 0.75 | ||
molecular function | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4095.32 (req: < 5)
Gene RIFs: 424 (req: <= 3)
Antibodies: 529 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4095.32 (req: >= 5)
Gene RIFs: 424 (req: > 3)
Antibodies: 529 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 147
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (4)
Protein-Protein Interactions (586)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (77)
Reactome (15)
KEGG (6)
PathwayCommons (19)
WikiPathways (37)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of SMO | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of SMO | ||||
Class B/2 (Secretin family receptors) | ||||
Disease | ||||
Diseases of signal transduction | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (155)
Functions (7)
Components (8)
Processes (140)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ParkinsonsUK-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 5 | 5 | 5 | 8.3 | 87.6 | ||||
creatinine measurement | 2 | 3 | 3 | 75.6 | |||||
urate measurement | 2 | 2 | 2 | 36.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 5 | 8.3 | 87.6 | ||||
creatinine measurement | 3 | 75.6 | |||||
urate measurement | 2 | 36.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | sonic hedgehog | 716553 | ||||||
Mouse | MGI:98297 | 20423 | ||||||
Rat | RGD:3673 | 29499 | ||||||
Dog | sonic hedgehog | VGNC:46147 | 608860 | |||||
Cow | sonic hedgehog | VGNC:34597 | 286821 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | sonic hedgehog | |||||
Mouse | ||||||
Rat | ||||||
Dog | sonic hedgehog | |||||
Cow | sonic hedgehog | |||||
Publication Statistics
PubMed Score 4095.32
PubMed score by year
PubTator Score 1269.68
PubTator score by year
Related Publications
Text Mined References (472)
GeneRif Annotations (424)
Items per page:
0 of 0
PMID | Year | Title |
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