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Tbio
SHCBP1
SHC SH2 domain-binding protein 1

Protein Summary
Description
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303383
  • ENSP00000306473
  • ENSG00000171241

Symbol
  • PAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
microRNA
0.73
gene perturbation
0.68
co-expressed gene
0.65
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.76   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.76   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.917
Data Source:  BioPlex,STRINGDB
PSG9
Tbio
Novelty:  0.0426075
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
KRBA1
Tdark
Novelty:  2.59384945
p_int:  0.999999248
p_ni:  7.52e-7
Data Source:  BioPlex
ZNF563
Tdark
Family:  TF
Novelty:  5.34386694
p_int:  0.999995635
p_ni:  0.000004365
Data Source:  BioPlex
ZNF574
Tdark
Family:  TF
Novelty:  2.72596185
p_int:  0.999995311
p_ni:  0.000004688
p_wrong:  1e-9
Data Source:  BioPlex
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999994954
p_ni:  0.000005046
Data Source:  BioPlex
ZNF276
Tdark
Family:  TF
Novelty:  0.3082638
p_int:  0.999987696
p_ni:  0.000012304
Data Source:  BioPlex
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
p_int:  0.999910888
p_ni:  0.000089112
Score:  0.179
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.999880601
p_ni:  0.000119347
p_wrong:  5.2e-8
Data Source:  BioPlex
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.999730528
p_ni:  0.000171488
p_wrong:  0.000097984
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SHC binding and spindle associated 1
VGNC:10144
745356
Macaque
SHC binding and spindle associated 1
716009
Mouse
MGI:1338802
20419
Rat
RGD:1590844
364648
Dog
SHC binding and spindle associated 1
VGNC:46143
475347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SHC binding and spindle associated 1
Macaque
SHC binding and spindle associated 1
Mouse
Rat
Dog
SHC binding and spindle associated 1
Publication Statistics
PubMed Score 20.76
PubMed score by year
PubTator Score 28.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title