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Tbio
SHC4
SHC-transforming protein 4

Protein Summary
Description
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332408
  • ENSP00000329668
  • ENSG00000185634
  • ENST00000396535
  • ENSP00000379786

Symbol
  • SHCD
  • RaLP
  • SHCD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
virus perturbation
0.83
histone modification site profile
0.77
protein domain
0.73
hub protein
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.38   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.38   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
NBEA
Tbio
Novelty:  0.02583687
p_int:  0.999999745
p_ni:  2.54e-7
p_wrong:  1e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
GAREM1
Tbio
Novelty:  0.21021078
p_int:  0.999982821
p_ni:  0.000017178
p_wrong:  1e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
p_int:  0.985127993
p_ni:  0.005328847
p_wrong:  0.00954316
Score:  0.38
Data Source:  BioPlex,STRINGDB
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
p_int:  0.979799393
p_ni:  0.020200607
Score:  0.194
Data Source:  BioPlex,STRINGDB
SHC3
Tbio
Novelty:  0.03638847
p_int:  0.933015105
p_ni:  1e-9
p_wrong:  0.066984894
Score:  0.71
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.982
Data Source:  STRINGDB
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
Score:  0.957
Data Source:  STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.956
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.928
Data Source:  STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets (28)
Explore Nearest Tclin Targets
1 – 5 of 27
ERBB2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  7
more:  3 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  13
more:  9 more common pathways
MET
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  7
more:  3 more common pathways
Pathways (46)
Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
EGFR tyrosine kinase inhibitor resistance
KEGG
Endocrine resistance
KEGG
Chronic myeloid leukemia
KEGG
Gastric cancer
KEGG
Focal adhesion
Name
Explore in Pharos
Explore in Source
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Chronic myeloid leukemia
Gastric cancer
Focal adhesion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
1
2
36.5
low density lipoprotein cholesterol measurement
1
1
1
31.4
alcohol consumption measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
2
36.5
low density lipoprotein cholesterol measurement
1
31.4
alcohol consumption measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SHC adaptor protein 4
VGNC:10419
453414
Macaque
SHC adaptor protein 4
714611
Mouse
MGI:2655364
271849
Rat
RGD:1583644
679845
Dog
SHC adaptor protein 4
VGNC:46142
487546
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SHC adaptor protein 4
Macaque
SHC adaptor protein 4
Mouse
Rat
Dog
SHC adaptor protein 4
Publication Statistics
PubMed Score 27.38
PubMed score by year
PubTator Score 37.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title