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Tbio
SHC3
SHC-transforming protein 3

Protein Summary
Description
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375835
  • ENSP00000364995
  • ENSG00000148082

Symbol
  • NSHC
  • SHCC
  • RAI
  • NSHC
  • SHCC
  • N-Shc
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.75
protein domain
0.73
transcription factor
0.72
virus perturbation
0.72
transcription factor binding site profile
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.57   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.57   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0