SHANK2
SH3 and multiple ankyrin repeat domains protein 2
Protein Summary
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities o ...more
- ENST00000409530
- ENSP00000387324
- ENSG00000162105
- ENST00000601538
- ENSP00000469689
- CORTBP1
- KIAA1022
- PROSAP1
- SHANK
- AUTS17
- CORTBP1
- CTTNBP1
- ProSAP1
- SPANK-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.85 | ||
protein domain | 0.85 | ||
cellular component | 0.75 | ||
disease perturbation | 0.74 | ||
transcription factor | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 163.87 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 294 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 163.87 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 294 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (115)
NLK
Family: Kinase
Novelty: 0.01512201
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.461
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (14)
Upstream (7)
Downstream (7)
1 – 5 of 7
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Neurexins and neuroligins | ||||
Reactome | Neuronal System | ||||
Reactome | Protein-protein interactions at synapses | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Neurexins and neuroligins | ||||
Neuronal System | ||||
Protein-protein interactions at synapses | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (4)
Components (16)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1 | 60.5 | |||||
1 | 1 | 1 | 47.7 | ||||||
vitamin D measurement | 1 | 1 | 1 | 32.7 | |||||
1 | 1 | 0 | 1.1 | 26.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1 | 60.5 | |||||
1 | 47.7 | ||||||
vitamin D measurement | 1 | 32.7 | |||||
0 | 1.1 | 26.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SH3 and multiple ankyrin repeat domains 2 | VGNC:13317 | 466694 | |||||
Macaque | SH3 and multiple ankyrin repeat domains 2 | 708192 | ||||||
Mouse | MGI:2671987 | 210274 | ||||||
Rat | RGD:628772 | 171093 | ||||||
Rat | RGD:9143352 | 103690160 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SH3 and multiple ankyrin repeat domains 2 | |||||
Macaque | SH3 and multiple ankyrin repeat domains 2 | |||||
Mouse | ||||||
Rat | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 163.87
PubMed score by year
PubTator Score 827.00
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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