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Tbio
SHANK1
SH3 and multiple ankyrin repeat domains protein 1

Protein Summary
Description
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. This gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family of proteins. Members of this family act as scaffold proteins that are required for the development and function of neuronal synapses. Deletions in this gene may be associated with autism spectrum disorder in males. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293441
  • ENSP00000293441
  • ENSG00000161681
  • ENST00000359082
  • ENSP00000351984
  • ENST00000391813
  • ENSP00000375689

Symbol
  • SSTRIP
  • SPANK-1
  • synamon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.86
molecular function
0.73
cellular component
0.72
interacting protein
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.34   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.34   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (146)
DLGAP1
Tbio
Novelty:  0.01576595
Score:  0.996
Data Source:  Reactome,STRINGDB
DLGAP3
Tbio
Novelty:  0.02019435
Score:  0.992
Data Source:  Reactome,STRINGDB
DLGAP2
Tbio
Novelty:  0.02137009
Score:  0.99
Data Source:  Reactome,STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
Score:  0.985
Data Source:  Reactome,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.985
Data Source:  Reactome,STRINGDB
DLGAP4
Tbio
Novelty:  0.06240351
Score:  0.981
Data Source:  Reactome,STRINGDB
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.979
Data Source:  Reactome,STRINGDB
HOMER3
Tbio
Novelty:  0.04408998
Score:  0.974
Data Source:  Reactome,STRINGDB
HOMER2
Tbio
Novelty:  0.00820449
Score:  0.974
Data Source:  Reactome,STRINGDB
GRM1
Tchem
Family:  GPCR
Novelty:  0.00099764
Score:  0.973
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (14)
Explore Nearest Tclin Targets
1 – 5 of 7
GRIN1
Tclin
Family:  Ion Channel
KEGG Distance:  3
Common Pathways:  1
GRIN3B
Tclin
Family:  Ion Channel
KEGG Distance:  3
Common Pathways:  1
GRIN3A
Tclin
Family:  Ion Channel
KEGG Distance:  3
Common Pathways:  1
GRIN2C
Tclin
Family:  Ion Channel
KEGG Distance:  3
Common Pathways:  1
GRIN2D
Tclin
Family:  Ion Channel
KEGG Distance:  3
Common Pathways:  1
Pathways (6)
Neurexins and neuroligins (R-HSA-6794361)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (50)
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Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
36.5
body mass index
1
1
1
35
body height
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
36.5
body mass index
1
35
body height
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 and multiple ankyrin repeat domains 1
468967
Macaque
SH3 and multiple ankyrin repeat domains 1
719673
Mouse
MGI:3613677
243961
Rat
RGD:621011
78957
Dog
SH3 and multiple ankyrin repeat domains 1
VGNC:53977
484359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 and multiple ankyrin repeat domains 1
Macaque
SH3 and multiple ankyrin repeat domains 1
Mouse
Rat
Dog
SH3 and multiple ankyrin repeat domains 1
Publication Statistics
PubMed Score 68.34
PubMed score by year
PubTator Score 24.72
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title