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Tbio
SH3TC2
SH3 domain and tetratricopeptide repeat-containing protein 2

Protein Summary
Description
This gene encodes a protein with two N-terminal Src homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR) motifs, and is a member of a small gene family. The gene product has been proposed to be an adapter or docking molecule. Mutations in this gene result in autosomal recessive Charcot-Marie-Tooth disease type 4C, a childhood-onset neurodegenerative disease characterized by demyelination of motor and sensory neurons. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000502274
  • ENSP00000421092
  • ENSG00000169247
  • ENST00000512049
  • ENSP00000421860
  • ENST00000515425
  • ENSP00000423660

Symbol
  • KIAA1985
  • MNMN
  • CMT4C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
microRNA
0.77
protein domain
0.58
small molecule perturbation
0.57
cell type or tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.39   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.39   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SBF2
Tbio
Novelty:  0.02647873
Score:  0.804
Data Source:  STRINGDB
GDAP1
Tbio
Novelty:  0.00682376
Score:  0.795
Data Source:  STRINGDB
FGD4
Tbio
Novelty:  0.01920119
Score:  0.761
Data Source:  STRINGDB
MTMR2
Tbio
Family:  Enzyme
Novelty:  0.01403122
Score:  0.759
Data Source:  STRINGDB
MPZ
Tbio
Novelty:  0.00223212
Score:  0.721
Data Source:  STRINGDB
ZNF792
Tdark
Family:  TF
Novelty:  171
Score:  0.686
Data Source:  STRINGDB
FIG4
Tbio
Family:  Enzyme
Novelty:  0.00742268
Score:  0.683
Data Source:  STRINGDB
GJB1
Tbio
Novelty:  0.00109019
Score:  0.679
Data Source:  STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
Score:  0.676
Data Source:  STRINGDB
PRX
Tbio
Novelty:  0.01867283
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.3
forced expiratory volume
1
1
1
69.4
peak expiratory flow
1
1
1
66.8
lymphocyte count
2
2
2
60.8
eosinophil percentage of leukocytes
1
2
2
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.3
forced expiratory volume
1
69.4
peak expiratory flow
1
66.8
lymphocyte count
2
60.8
eosinophil percentage of leukocytes
2
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain and tetratricopeptide repeats 2
VGNC:4162
471691
Macaque
SH3 domain and tetratricopeptide repeats 2
709970
Mouse
MGI:2444417
225608
Rat
RGD:1309038
307393
Dog
SH3 domain and tetratricopeptide repeats 2
VGNC:46136
489197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain and tetratricopeptide repeats 2
Macaque
SH3 domain and tetratricopeptide repeats 2
Mouse
Rat
Dog
SH3 domain and tetratricopeptide repeats 2
Publication Statistics
PubMed Score 52.39
PubMed score by year
PubTator Score 50.99
PubTator score by year
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Related Publications
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PMID
Year
Title