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Tbio
SH3RF2
E3 ubiquitin-protein ligase SH3RF2

Protein Summary
Description
Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359120
  • ENSP00000352028
  • ENSG00000156463
  • ENST00000511217
  • ENSP00000424497

Symbol
  • POSH3
  • POSHER
  • PPP1R39
  • RNF158
  • HEPP1
  • POSHER
  • RNF158
  • PPP1R39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.83
tissue sample
0.74
molecular function
0.73
PubMedID
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
p_int:  0.999315376
p_ni:  0.000164626
p_wrong:  0.000519998
Data Source:  BioPlex
CENPJ
Tbio
Novelty:  0.01337231
p_int:  0.960423278
p_ni:  0.000049683
p_wrong:  0.039527039
Score:  0.689
Data Source:  BioPlex,STRINGDB
ZCCHC24
Tdark
Novelty:  0.36752754
Score:  0.701
Data Source:  STRINGDB
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
Score:  0.682
Data Source:  STRINGDB
OR5I1
Tdark
Family:  oGPCR
Novelty:  0.55486572
Score:  0.619
Data Source:  STRINGDB
PAK4
Tchem
Family:  Kinase
Novelty:  0.0068821
Score:  0.617
Data Source:  STRINGDB
DPY19L1
Tdark
Family:  Enzyme
Novelty:  0.34765717
Score:  0.571
Data Source:  STRINGDB
VSTM2A
Tbio
Novelty:  0.34891628
Score:  0.569
Data Source:  STRINGDB
PLAC8L1
Tdark
Novelty:  2.10744169
Score:  0.547
Data Source:  STRINGDB
SP4
Tbio
Family:  TF
Novelty:  0.02444442
Score:  0.546
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
39.6
1
1
0
5.5
15.8
age at onset
1
1
0
5.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
39.6
0
5.5
15.8
age at onset
0
5.5
15.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing ring finger 2
VGNC:4161
462165
Macaque
SH3 domain containing ring finger 2
707158
Mouse
MGI:2444628
269016
Rat
RGD:1308415
307472
Dog
SH3 domain containing ring finger 2
VGNC:46133
478049
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing ring finger 2
Macaque
SH3 domain containing ring finger 2
Mouse
Rat
Dog
SH3 domain containing ring finger 2
Publication Statistics
PubMed Score 10.76
PubMed score by year
PubTator Score 3.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title