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Tbio
SH3RF1
E3 ubiquitin-protein ligase SH3RF1

Protein Summary
Description
Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284637
  • ENSP00000284637
  • ENSG00000154447

Symbol
  • KIAA1494
  • POSH
  • POSH1
  • RNF142
  • SH3MD2
  • POSH
  • RNF142
  • SH3MD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
virus perturbation
0.85
transcription factor perturbation
0.84
interacting protein
0.71
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.59   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.59   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (284)
SIAH2
Tbio
Family:  Enzyme
Novelty:  0.01461174
Score:  0.966
Data Source:  STRINGDB
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
Score:  0.961
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.959
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.956
Data Source:  STRINGDB
UBE2Z
Tbio
Novelty:  0.11461616
Score:  0.953
Data Source:  STRINGDB
UBE2U
Tdark
Novelty:  0.6547947
Score:  0.952
Data Source:  STRINGDB
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
Score:  0.952
Data Source:  STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.949
Data Source:  STRINGDB
UNKL
Tdark
Family:  Enzyme
Novelty:  1.37466055
Score:  0.945
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
21
self reported educational attainment
1
1
1
3.6
intelligence
1
1
1
3.6
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
21
self reported educational attainment
1
3.6
intelligence
1
3.6
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing ring finger 1
VGNC:685
461598
Macaque
SH3 domain containing ring finger 1
694082
Mouse
MGI:1913066
59009
Rat
RGD:735154
306417
Dog
SH3 domain containing ring finger 1
VGNC:46132
612744
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing ring finger 1
Macaque
SH3 domain containing ring finger 1
Mouse
Rat
Dog
SH3 domain containing ring finger 1
Publication Statistics
PubMed Score 61.59
PubMed score by year
PubTator Score 35.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title