Protein Summary
May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking ...more
- ENST00000370558
- ENSP00000473267
- ENSG00000097033
- ENST00000482504
- ENSP00000418744
- ENST00000535010
- ENSP00000441355
- KIAA0491
- Bif-1
- CGI-61
- PPP1R70
- dJ612B15.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.99 | ||
disease perturbation | 0.96 | ||
viral protein | 0.8 | ||
virus perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.13 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 514 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.13 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 514 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (90)
SERPINB3
Novelty: 0.00325244
p_int: 0.99951078
p_ni: 0.000089093
p_wrong: 0.000400127
Score: 0.525
Data Source: BioPlex,STRINGDB
FCGRT
Novelty: 0.00105713
p_int: 0.998922515
p_ni: 0.001077472
p_wrong: 1.2e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
SERPINB13
Novelty: 0.01753451
p_int: 0.765051909
p_ni: 0.000063737
p_wrong: 0.234884354
Score: 0.194
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (6)
Downstream (6)
1 – 5 of 6
Pathways (4)
KEGG (2)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Endocytosis | ||||
KEGG | Autophagy - animal | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Endocytosis | ||||
Autophagy - animal | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (4)
Components (7)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | HGNC | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | SH3 domain containing GRB2 like, endophilin B1 | VGNC:8485 | 456993 | |||||
Macaque | SH3 domain containing GRB2 like, endophilin B1 | 712393 | ||||||
Mouse | MGI:1859730 | 54673 | ||||||
Rat | RGD:1304859 | 292156 | ||||||
Dog | SH3 domain containing GRB2 like, endophilin B1 | VGNC:46127 | 612505 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | SH3 domain containing GRB2 like, endophilin B1 | |||||
Macaque | SH3 domain containing GRB2 like, endophilin B1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SH3 domain containing GRB2 like, endophilin B1 | |||||
Publication Statistics
PubMed Score 38.13
PubMed score by year
PubTator Score 22.15
PubTator score by year
Related Publications
Text Mined References (51)
GeneRif Annotations (24)
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