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Tbio
SH3GLB1
Endophilin-B1

Protein Summary
Description
May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370558
  • ENSP00000473267
  • ENSG00000097033
  • ENST00000482504
  • ENSP00000418744
  • ENST00000535010
  • ENSP00000441355

Symbol
  • KIAA0491
  • Bif-1
  • CGI-61
  • PPP1R70
  • dJ612B15.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
disease perturbation
0.96
viral protein
0.8
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.13   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 514   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.13   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
SERPINB3
Tbio
Novelty:  0.00325244
p_int:  0.99951078
p_ni:  0.000089093
p_wrong:  0.000400127
Score:  0.525
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.998922515
p_ni:  0.001077472
p_wrong:  1.2e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.765051909
p_ni:  0.000063737
p_wrong:  0.234884354
Score:  0.194
Data Source:  BioPlex,STRINGDB
UVRAG
Tbio
Novelty:  0.01081083
Score:  0.982
Data Source:  STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
Score:  0.941
Data Source:  STRINGDB
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
Score:  0.939
Data Source:  STRINGDB
XPO7
Tbio
Novelty:  0.05412704
Score:  0.904
Data Source:  STRINGDB
DSCR3
Tbio
Novelty:  0.05414856
Score:  0.904
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.901
Data Source:  STRINGDB
ATG9A
Tbio
Novelty:  0.01995033
Score:  0.881
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
FGFR3
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR2
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  2
PDGFRA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like, endophilin B1
VGNC:8485
456993
Macaque
SH3 domain containing GRB2 like, endophilin B1
712393
Mouse
MGI:1859730
54673
Rat
RGD:1304859
292156
Dog
SH3 domain containing GRB2 like, endophilin B1
VGNC:46127
612505
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like, endophilin B1
Macaque
SH3 domain containing GRB2 like, endophilin B1
Mouse
Rat
Dog
SH3 domain containing GRB2 like, endophilin B1
Publication Statistics
PubMed Score 38.13
PubMed score by year
PubTator Score 22.15
PubTator score by year
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Related Publications
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PMID
Year
Title