Tbio SH3GLB1 Endophilin-B1

Protein Summary

Description

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q9Y371
• B4E182
• Q5H8U5
• Q9H3Z0
• Q9NR47
• Q9NYA9

Gene Name

• SH3GLB1

Ensembl ID

• ENST00000370558
• ENSP00000473267
• ENSG00000097033
• ENST00000482504
• ENSP00000418744
• ENST00000535010
• ENSP00000441355

Symbol

• KIAA0491
• Bif-1
• CGI-61
• PPP1R70
• dJ612B15.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.99
disease perturbation	0.96
viral protein	0.8
virus perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.13   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 514   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.13   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

SERPINB3

Tbio

Novelty:  0.00325244

p_int:  0.99951078

p_ni:  0.000089093

p_wrong:  0.000400127

Score:  0.525

Data Source:  BioPlex,STRINGDB

FCGRT

Tclin

Novelty:  0.00105713

p_int:  0.998922515

p_ni:  0.001077472

p_wrong:  1.2e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

SERPINB13

Tbio

Novelty:  0.01753451

p_int:  0.765051909

p_ni:  0.000063737

p_wrong:  0.234884354

Score:  0.194

Data Source:  BioPlex,STRINGDB

UVRAG

Tbio

Novelty:  0.01081083

Score:  0.982

Data Source:  STRINGDB

CCDC22

Tbio

Novelty:  0.01400901

Score:  0.941

Data Source:  STRINGDB

SH3KBP1

Tbio

Family:  Enzyme

Novelty:  0.01454593

Score:  0.939

Data Source:  STRINGDB

XPO7

Tbio

Novelty:  0.05412704

Score:  0.904

Data Source:  STRINGDB

DSCR3

Tbio

Novelty:  0.05414856

Score:  0.904

Data Source:  STRINGDB

BECN1

Tbio

Novelty:  0.0003792

Score:  0.901

Data Source:  STRINGDB

ATG9A

Tbio

Novelty:  0.01995033

Score:  0.881

Data Source:  STRINGDB

Nearest Tclin Targets (6)

Explore Nearest Tclin Targets

Downstream (6)

1 – 5 of 6

FGFR3

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Endocytosis

FGFR2

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Endocytosis

FGFR4

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Endocytosis

IGF1R

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  2

1: Endocytosis

2: Autophagy - animal

PDGFRA

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Endocytosis

Pathways (4)

KEGG (2)

WikiPathways (2)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144
KEGG	Autophagy - animal	137 targets	path:hsa04140

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144
Autophagy - animal	137 targets	path:hsa04140

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (4)

Components (7)

Processes (17)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein homodimerization activity	Inferred from Physical Interaction (IPI)	HGNC
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
lipid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Apoptosis
Autophagy
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Lipid-binding

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SH3 domain containing GRB2 like, endophilin B1	VGNC:8485	456993
Macaque	SH3 domain containing GRB2 like, endophilin B1		712393
Mouse	SH3-domain GRB2-like B1 (endophilin)	MGI:1859730	54673
Rat	SH3 domain -containing GRB2-like endophilin B1	RGD:1304859	292156
Dog	SH3 domain containing GRB2 like, endophilin B1	VGNC:46127	612505

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SH3 domain containing GRB2 like, endophilin B1
Macaque	SH3 domain containing GRB2 like, endophilin B1
Mouse	SH3-domain GRB2-like B1 (endophilin)
Rat	SH3 domain -containing GRB2-like endophilin B1
Dog	SH3 domain containing GRB2 like, endophilin B1

Publication Statistics

PubMed Score 38.13

PubMed score by year

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PubTator Score 22.15

PubTator score by year

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Related Publications

Text Mined References (51)

GeneRif Annotations (24)

Items per page:

10

0 of 0

PMID	Year	Title