Tbio SH3GL3 Endophilin-A3

Protein Summary

Description

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Uniprot Accession IDs

• Q99963
• O43553
• O43554

Gene Name

• SH3GL3

Ensembl ID

• ENST00000324537
• ENSP00000320092
• ENSG00000140600
• ENST00000427482
• ENSP00000391372

Symbol

• CNSA3
• SH3D2C
• CNSA3
• EEN-B2
• SH3D2C
• SH3P13
• HsT19371

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.88
histone modification site profile	0.7
disease perturbation	0.68
protein domain	0.58
PubMedID	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.85   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.85   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0