Tbio SH3GL2 Endophilin-A1

Protein Summary

Description

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

Uniprot Accession IDs

• Q99962
• B2R618
• Q9NQK5

Gene Name

• SH3GL2

Ensembl ID

• ENST00000380607
• ENSP00000369981
• ENSG00000107295

Symbol

• CNSA2
• SH3D2A
• CNSA2
• SH3P4
• EEN-B1
• SH3D2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
trait	0.93
interacting protein	0.81
PubMedID	0.74
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.72   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 312   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.72   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0