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Tbio
SH3GL1
Endophilin-A2

Protein Summary
Description
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269886
  • ENSP00000269886
  • ENSG00000141985
  • ENST00000417295
  • ENSP00000404568
  • ENST00000598564
  • ENSP00000470792

Symbol
  • CNSA1
  • SH3D2B
  • EEN
  • CNSA1
  • SH3P8
  • SH3D2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
disease perturbation
0.83
transcription factor
0.74
kinase perturbation
0.71
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.52   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.52   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (214)
SH3GL2
Tbio
Novelty:  0.0188955
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
SH3GL3
Tbio
Novelty:  0.05467913
p_int:  0.999999324
p_ni:  6.76e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
ARHGAP8
Tbio
Family:  Enzyme
Novelty:  0.22016818
p_int:  0.99999648
p_ni:  0.00000352
Score:  0.593
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.999445404
p_ni:  0.000554596
Score:  0.22
Data Source:  BioPlex,STRINGDB
AZU1
Tbio
Family:  Enzyme
Novelty:  0.00267169
p_int:  0.999152966
p_ni:  0.000847034
Score:  0.588
Data Source:  BioPlex,STRINGDB
DPPA4
Tbio
Novelty:  0.05764302
p_int:  0.998628616
p_ni:  0.001371384
Score:  0.338
Data Source:  BioPlex,STRINGDB
TPTE2
Tbio
Family:  Enzyme
Novelty:  0.04710658
p_int:  0.984309031
p_ni:  0.015690969
Score:  0.153
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.980773529
p_ni:  0.019226471
Data Source:  BioPlex
C8G
Tbio
Novelty:  0.02322575
p_int:  0.973885829
p_ni:  0.026114133
p_wrong:  3.8e-8
Score:  0.232
Data Source:  BioPlex,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.937358782
p_ni:  0.062641218
Score:  0.151
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
FGFR3
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
EGFR
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
PDGFRA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR2
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Pathways (19)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Disease
Reactome
EGFR downregulation
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Disease
EGFR downregulation
Infectious disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
5
96.6
mean corpuscular volume
2
2
2
95.6
hemoglobin measurement
1
2
2
90.3
hematocrit
2
2
3
88.5
mean reticulocyte volume
1
1
1
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
96.6
mean corpuscular volume
2
95.6
hemoglobin measurement
2
90.3
hematocrit
3
88.5
mean reticulocyte volume
1
87.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like 1, endophilin A2
VGNC:14754
738129
Mouse
MGI:700010
20405
Rat
RGD:708456
81922
Dog
SH3 domain containing GRB2 like 1, endophilin A2
VGNC:46124
485039
Horse
SH3 domain containing GRB2 like 1, endophilin A2
VGNC:22939
100146122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like 1, endophilin A2
Mouse
Rat
Dog
SH3 domain containing GRB2 like 1, endophilin A2
Horse
SH3 domain containing GRB2 like 1, endophilin A2
Publication Statistics
PubMed Score 44.52
PubMed score by year
PubTator Score 26.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title