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Tbio
SH3BP4
SH3 domain-binding protein 4

Protein Summary
Description
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344528
  • ENSP00000340237
  • ENSG00000130147
  • ENST00000392011
  • ENSP00000375867
  • ENST00000409212
  • ENSP00000386862

Symbol
  • BOG25
  • EHB10
  • TTP
  • TTP
  • BOG25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
biological process
0.67
microRNA
0.67
PubMedID
0.66
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.5   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.5   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.999989254
p_ni:  0.000004466
p_wrong:  0.000006281
Data Source:  BioPlex
GIPC2
Tbio
Novelty:  0.21044026
p_int:  0.999925701
p_ni:  0.000074296
p_wrong:  3e-9
Score:  0.573
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999534168
p_ni:  0.000315985
p_wrong:  0.000149847
Data Source:  BioPlex
Q8NFQ8
Tbio
Novelty:  0.08912351
p_int:  0.999400666
p_ni:  0.000561628
p_wrong:  0.000037705
Data Source:  BioPlex
VSIG4
Tbio
Novelty:  0.01671671
p_int:  0.997949574
p_ni:  0.001661805
p_wrong:  0.000388621
Data Source:  BioPlex
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.996557598
p_ni:  0.003163873
p_wrong:  0.000278529
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.923941308
p_ni:  0.000138979
p_wrong:  0.075919713
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.909192622
p_ni:  0.000234652
p_wrong:  0.090572726
Score:  0.15
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.801
Data Source:  STRINGDB
RRAGC
Tbio
Novelty:  0.01462756
Score:  0.734
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
59.8
platelet crit
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
59.8
platelet crit
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain binding protein 4
VGNC:6373
460040
Macaque
SH3 domain binding protein 4
693393
Mouse
MGI:2138297
98402
Rat
RGD:620219
64634
Dog
SH3 domain binding protein 4
VGNC:46119
486172
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain binding protein 4
Macaque
SH3 domain binding protein 4
Mouse
Rat
Dog
SH3 domain binding protein 4
Publication Statistics
PubMed Score 8.50
PubMed score by year
PubTator Score 11.03
PubTator score by year
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Related Publications
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PMID
Year
Title