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Tdark
SH2D5
SH2 domain-containing protein 5

Protein Summary
Description
May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375031
  • ENSP00000364171
  • ENSG00000189410
  • ENST00000444387
  • ENSP00000406026
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
gene perturbation
0.59
microRNA
0.59
cell type or tissue
0.51
virus perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
PDZK1P1
Tdark
p_int:  0.999998629
p_wrong:  0.00000137
Data Source:  BioPlex
CTXN1
Tdark
Novelty:  0.0598686
Score:  0.748
Data Source:  STRINGDB
OLFML1
Tdark
Novelty:  0.27791923
Score:  0.714
Data Source:  STRINGDB
SH2D1B
Tbio
Novelty:  0.01535146
Score:  0.595
Data Source:  STRINGDB
BCR
Tclin
Novelty:  0.00127709
Score:  0.57
Data Source:  STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
Score:  0.567
Data Source:  STRINGDB
SH2D1A
Tbio
Novelty:  0.0060687
Score:  0.553
Data Source:  STRINGDB
GLDN
Tbio
Novelty:  0.01859604
Score:  0.532
Data Source:  STRINGDB
STAP2
Tbio
Novelty:  0.00375696
Score:  0.529
Data Source:  STRINGDB
STAP1
Tbio
Novelty:  0.17498048
Score:  0.524
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
88.3
chronotype measurement
2
2
1
1
81
risk-taking behaviour
1
1
1
56.6
household income
1
2
2
45.6
wellbeing measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
88.3
chronotype measurement
1
1
81
risk-taking behaviour
1
56.6
household income
2
45.6
wellbeing measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 5
VGNC:10996
749040
Macaque
SH2 domain containing 5
717509
Mouse
MGI:2446215
230863
Rat
RGD:1305952
366489
Dog
SH2 domain containing 5
VGNC:52924
100686893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 5
Macaque
SH2 domain containing 5
Mouse
Rat
Dog
SH2 domain containing 5
Publication Statistics
PubMed Score 1.94
PubMed score by year
PubTator Score 0.83
PubTator score by year
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Related Publications
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PMID
Year
Title