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Tbio
SH2D4A
SH2 domain-containing protein 4A

Protein Summary
Description
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265807
  • ENSP00000265807
  • ENSG00000104611
  • ENST00000518040
  • ENSP00000429482
  • ENST00000519207
  • ENSP00000428684

Symbol
  • PPP1R38
  • SH2A
  • SH2A
  • PPP1R38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
tissue sample
0.66
histone modification site profile
0.64
transcription factor
0.56
transcription factor binding site profile
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0