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Tbio
SGSM1
Small G protein signaling modulator 1

Protein Summary
Description
Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400358
  • ENSP00000383211
  • ENSG00000167037
  • ENST00000400359
  • ENSP00000383212

Symbol
  • KIAA1941
  • RUTBC2
  • RUTBC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.55
tissue
0.53
phenotype
0.52
cell line
0.5
disease
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.6   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.6   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999997614
p_ni:  0.000002373
p_wrong:  1.4e-8
Score:  0.396
Data Source:  BioPlex,STRINGDB
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.999996531
p_ni:  0.000003469
Score:  0.283
Data Source:  BioPlex,STRINGDB
PDGFRL
Tbio
Novelty:  0.0709225
p_int:  0.999776464
p_ni:  0.000221652
p_wrong:  0.000001884
Data Source:  BioPlex
PIP4P2
Tbio
Family:  Enzyme
Novelty:  0.94294105
p_int:  0.999203077
p_ni:  0.000044647
p_wrong:  0.000752276
Data Source:  BioPlex
ABCB10
Tbio
Family:  Transporter
Novelty:  0.00351852
p_int:  0.991801764
p_ni:  0.008198236
Data Source:  BioPlex
OCIAD1
Tbio
Novelty:  0.05701069
p_int:  0.990009896
p_ni:  0.009990104
Data Source:  BioPlex
ACADVL
Tbio
Family:  Enzyme
Novelty:  0.00383705
p_int:  0.988762366
p_ni:  0.011237634
Data Source:  BioPlex
RANBP3
Tbio
Novelty:  0.02563424
p_int:  0.930576195
p_ni:  0.069423799
p_wrong:  6e-9
Data Source:  BioPlex
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.881159771
p_ni:  0.118840229
Data Source:  BioPlex
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
11
11
98.7
heel bone mineral density
2
1
2
37.6
1
1
0
1.9
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
11
98.7
heel bone mineral density
2
37.6
0
1.9
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small G protein signaling modulator 1
VGNC:6014
465179
Macaque
small G protein signaling modulator 1
714057
Mouse
MGI:107320
52850
Rat
RGD:1308178
288743
Dog
small G protein signaling modulator 1
VGNC:46105
486324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small G protein signaling modulator 1
Macaque
small G protein signaling modulator 1
Mouse
Rat
Dog
small G protein signaling modulator 1
Publication Statistics
PubMed Score 4.60
PubMed score by year
PubTator Score 1.91
PubTator score by year
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Related Publications
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PMID
Year
Title