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Tbio
SGPP1
Sphingosine-1-phosphate phosphatase 1

Protein Summary
Description
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phoshate, lysophosphatidic acid or phosphatidic acid. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:12815058, PubMed:11756451). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide though a phosphorylation/dephosphorylation cycle. Regulates intracellular ceramide levels, which in turn regulate apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247225
  • ENSP00000247225
  • ENSG00000126821
  • ENST00000645915
  • ENSP00000496280
  • ENSG00000285281

Symbol
  • SPPase1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.78
PubMedID
0.75
gene perturbation
0.7
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.96   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.96   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.998267416
p_ni:  0.001732584
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.992352382
p_ni:  0.007647618
Data Source:  BioPlex
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.991734451
p_ni:  0.008265549
Score:  0.172
Data Source:  BioPlex,STRINGDB
SYP
Tbio
Novelty:  0.00021543
p_int:  0.96575484
p_ni:  0.034245156
p_wrong:  4e-9
Data Source:  BioPlex
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
p_int:  0.936817574
p_ni:  0.063182421
p_wrong:  5e-9
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.932058042
p_ni:  0.067941958
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.923602561
p_ni:  0.076397439
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.912840048
p_ni:  0.079952
p_wrong:  0.007207953
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.895036119
p_ni:  0.099803375
p_wrong:  0.005160506
Data Source:  BioPlex
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.85611422
p_ni:  0.143783757
p_wrong:  0.000102022
Data Source:  BioPlex
Pathways (8)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (56)
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
22
11
31
99.4
ceramide measurement
22
11
31
99.4
triglyceride measurement
13
12
22
99
triglyceride measurement
13
12
22
99
sphingomyelin measurement
30
203
286
8.7
99
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
31
99.4
ceramide measurement
31
99.4
triglyceride measurement
22
99
triglyceride measurement
22
99
sphingomyelin measurement
286
8.7
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate phosphatase 1
VGNC:6777
467479
Mouse
MGI:2135760
81535
Rat
RGD:727829
81536
Dog
sphingosine-1-phosphate phosphatase 1
VGNC:46103
490728
Cow
sphingosine-1-phosphate phosphatase 1
VGNC:34548
516881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate phosphatase 1
Mouse
Rat
Dog
sphingosine-1-phosphate phosphatase 1
Cow
sphingosine-1-phosphate phosphatase 1
Publication Statistics
PubMed Score 21.96
PubMed score by year
PubTator Score 11.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title