Protein Summary
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.
- ENST00000357799
- ENSP00000350447
- ENSG00000163535
- ENST00000409203
- ENSP00000386249
- SGOL2
- SGOL2
- TRIPIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.82 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.82 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (199)
PPP2R2D
Family: Enzyme
Novelty: 0.0658328
p_int: 0.999999917
p_ni: 8.3e-8
Score: 0.541
Data Source: BioPlex,STRINGDB
LYPLA2
Family: Enzyme
Novelty: 0.05436006
p_int: 0.999811438
p_ni: 0.000188538
p_wrong: 2.4e-8
Score: 0.186
Data Source: BioPlex,STRINGDB
H3F3A
Novelty: 0.00508186
p_int: 0.999656444
p_ni: 2.93e-7
p_wrong: 0.000343263
Data Source: BioPlex
DUSP14
Family: Enzyme
Novelty: 0.04013065
p_int: 0.999524411
p_ni: 0.000470419
p_wrong: 0.00000517
Data Source: BioPlex
LYG2
Family: Enzyme
Novelty: 0.12091256
p_int: 0.998851984
p_ni: 0.001148016
Data Source: BioPlex
PPP2CA
Family: Enzyme
Novelty: 0.00496839
p_int: 0.996924434
p_ni: 0.003075566
Score: 0.949
Data Source: BioPlex,STRINGDB
PKP3
Novelty: 0.0269462
p_int: 0.995934231
p_ni: 0.004065553
p_wrong: 2.16e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | shugoshin 2 | VGNC:9053 | 459862 | |||||
Mouse | MGI:3644562 | 244495 | ||||||
Rat | RGD:1308450 | 316425 | ||||||
Dog | shugoshin 2 | VGNC:46101 | 478863 | |||||
Horse | shugoshin 2 | VGNC:22921 | 100070958 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | shugoshin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | shugoshin 2 | |||||
Horse | shugoshin 2 | |||||
Publication Statistics
PubMed Score 22.82
PubMed score by year
PubTator Score 9.77
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (6)
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