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Tbio
SGO1
Shugoshin 1

Protein Summary
Description
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometapha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263753
  • ENSP00000263753
  • ENSG00000129810
  • ENST00000306698
  • ENSP00000306581
  • ENST00000412997
  • ENSP00000410458
  • ENST00000417364
  • ENSP00000394613
  • ENST00000419233
  • ENSP00000394625
  • ENST00000421451
  • ENSP00000414129
  • ENST00000425061
  • ENSP00000414960
  • ENST00000437051
  • ENSP00000389034
  • ENST00000442720
  • ENSP00000394957
  • ENST00000443724
  • ENSP00000413070
  • ENST00000452020
  • ENSP00000411200

Symbol
  • SGOL1
  • SGO
  • CAID
  • SGOL1
  • NY-BR-85
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.57   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.57   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0