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Tchem
SGMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

Protein Summary
Description
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359079
  • ENSP00000351981
  • ENSG00000164023
  • ENST00000394684
  • ENSP00000378176
  • ENST00000394686
  • ENSP00000378178

Symbol
  • SMS2
  • SMS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.97
microRNA
0.69
transcription factor perturbation
0.68
PubMedID
0.66
cellular component
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.25   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.25   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (46)
CHEMBL4641888
Rendered image for CHEMBL4641888
CHEMBL4172856
Rendered image for CHEMBL4172856
compound D24 [PMID: 24374347]
Rendered image for compound D24 [PMID: 24374347]
CHEMBL4177314
Rendered image for CHEMBL4177314
CHEMBL4646354
Rendered image for CHEMBL4646354
CHEMBL4645607
Rendered image for CHEMBL4645607
CHEMBL4203399
Rendered image for CHEMBL4203399
CHEMBL4638337
Rendered image for CHEMBL4638337
Protein-Protein Interactions (57)
SMPD1
Tchem
Family:  Enzyme
Novelty:  0.00199663
Score:  0.97
Data Source:  STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
Score:  0.966
Data Source:  STRINGDB
ASAH2
Tbio
Family:  Enzyme
Novelty:  0.01413539
Score:  0.966
Data Source:  STRINGDB
DEGS1
Tchem
Family:  Enzyme
Novelty:  0.00300325
Score:  0.964
Data Source:  STRINGDB
DEGS2
Tbio
Family:  Enzyme
Novelty:  0.02360852
Score:  0.963
Data Source:  STRINGDB
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
Score:  0.961
Data Source:  STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
Score:  0.961
Data Source:  STRINGDB
ACER2
Tchem
Family:  Enzyme
Novelty:  0.040885
Score:  0.96
Data Source:  STRINGDB
ACER1
Tbio
Family:  Enzyme
Novelty:  0.05571844
Score:  0.959
Data Source:  STRINGDB
SMPD3
Tchem
Family:  Enzyme
Novelty:  0.01053328
Score:  0.958
Data Source:  STRINGDB
Pathways (9)
Metabolism (R-HSA-1430728)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sphingomyelin synthase 2
695947
Mouse
MGI:1921692
74442
Rat
RGD:1305778
310849
Dog
sphingomyelin synthase 2
VGNC:46099
478505
Horse
sphingomyelin synthase 2
VGNC:22919
100072971
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sphingomyelin synthase 2
Mouse
Rat
Dog
sphingomyelin synthase 2
Horse
sphingomyelin synthase 2
Publication Statistics
PubMed Score 79.25
PubMed score by year
PubTator Score 51.94
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title