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Tchem
SGMS1
Phosphatidylcholine:ceramide cholinephosphotransferase 1

Protein Summary
Description
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361781
  • ENSP00000354829
  • ENSG00000198964

Symbol
  • MOB
  • SMS1
  • TMEM23
  • MOB
  • MOB1
  • SMS1
  • TMEM23
  • hmob33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.99
metabolite
0.97
transcription factor perturbation
0.94
virus perturbation
0.92
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.26   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.26   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (75)
DEGS2
Tbio
Family:  Enzyme
Novelty:  0.02360852
Score:  0.976
Data Source:  STRINGDB
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
Score:  0.968
Data Source:  STRINGDB
DEGS1
Tchem
Family:  Enzyme
Novelty:  0.00300325
Score:  0.968
Data Source:  STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
Score:  0.967
Data Source:  STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
Score:  0.966
Data Source:  STRINGDB
SMPD4
Tbio
Family:  Enzyme
Novelty:  0.08266114
Score:  0.962
Data Source:  STRINGDB
SGPP2
Tbio
Family:  Enzyme
Novelty:  0.09408823
Score:  0.962
Data Source:  STRINGDB
SMPD1
Tchem
Family:  Enzyme
Novelty:  0.00199663
Score:  0.96
Data Source:  STRINGDB
ASAH2
Tbio
Family:  Enzyme
Novelty:  0.01413539
Score:  0.96
Data Source:  STRINGDB
SMPD3
Tchem
Family:  Enzyme
Novelty:  0.01053328
Score:  0.959
Data Source:  STRINGDB
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
2
2
67.5
triglyceride measurement
2
2
2
63
low density lipoprotein cholesterol measurement
2
2
2
61.8
apolipoprotein B measurement
2
2
2
58.9
mathematical ability
2
2
2
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
67.5
triglyceride measurement
2
63
low density lipoprotein cholesterol measurement
2
61.8
apolipoprotein B measurement
2
58.9
mathematical ability
2
31.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin synthase 1
VGNC:7260
450460
Macaque
sphingomyelin synthase 1
704027
Mouse
MGI:2444110
208449
Rat
RGD:727912
353229
Dog
sphingomyelin synthase 1
VGNC:46098
477582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin synthase 1
Macaque
sphingomyelin synthase 1
Mouse
Rat
Dog
sphingomyelin synthase 1
Publication Statistics
PubMed Score 62.26
PubMed score by year
PubTator Score 233.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title