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Tchem
SGK2
Serine/threonine-protein kinase Sgk2

Protein Summary
Description
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341458
  • ENSP00000340608
  • ENSG00000101049
  • ENST00000373092
  • ENSP00000362184
  • ENST00000373100
  • ENSP00000362192
  • ENST00000423407
  • ENSP00000392795
  • ENST00000426287
  • ENSP00000412214

Symbol
  • H-SGK2
  • dJ138B7.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
cell type or tissue
0.8
cell line
0.64
small molecule perturbation
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.86   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.86   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (59)
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
Score:  0.964
Data Source:  Reactome,STRINGDB
PDPK1
Tchem
Family:  Kinase
Novelty:  0.00430458
Score:  0.944
Data Source:  STRINGDB
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
Score:  0.926
Data Source:  Reactome,STRINGDB
SCNN1G
Tclin
Family:  IC
Novelty:  0.00689941
Score:  0.919
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.915
Data Source:  STRINGDB
SCNN1B
Tclin
Family:  IC
Novelty:  0.01281284
Score:  0.915
Data Source:  STRINGDB
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
Score:  0.914
Data Source:  Reactome,STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.911
Data Source:  Reactome,STRINGDB
SCNN1A
Tclin
Family:  IC
Novelty:  0.00900102
Score:  0.908
Data Source:  STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
Score:  0.905
Data Source:  STRINGDB
Pathways (152)
Ion channel transport (R-HSA-983712)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
66
2
2
2
65.3
reticulocyte measurement
1
1
1
49.5
mean reticulocyte volume
1
1
1
46.1
reticulocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
66
2
65.3
reticulocyte measurement
1
49.5
mean reticulocyte volume
1
46.1
reticulocyte count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SGK2, serine/threonine kinase 2
VGNC:10267
740699
Macaque
SGK2, serine/threonine kinase 2
695356
Mouse
MGI:1351318
27219
Rat
RGD:620232
171497
Horse
SGK2, serine/threonine kinase 2
VGNC:22917
100147213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SGK2, serine/threonine kinase 2
Macaque
SGK2, serine/threonine kinase 2
Mouse
Rat
Horse
SGK2, serine/threonine kinase 2
Publication Statistics
PubMed Score 12.86
PubMed score by year
PubTator Score 12.44
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title