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Tchem
SGK1
Serine/threonine-protein kinase Sgk1

Protein Summary
Description
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237305
  • ENSP00000237305
  • ENSG00000118515
  • ENST00000367857
  • ENSP00000356831
  • ENST00000367858
  • ENSP00000356832
  • ENST00000413996
  • ENSP00000396242
  • ENST00000528577
  • ENSP00000434450

Symbol
  • SGK
  • SGK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.98
biological term
0.97
small molecule perturbation
0.97
transcription factor perturbation
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 869.93   (req: < 5)
Gene RIFs: 182   (req: <= 3)
Antibodies: 821   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 869.93   (req: >= 5)
Gene RIFs: 182   (req: > 3)
Antibodies: 821   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 53
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0