Protein Summary
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity). The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.91 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 18 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.91 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 18 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (41)
RANGRF
Family: Enzyme
Novelty: 0.02750539
p_int: 0.999992685
p_ni: 0.00000607
p_wrong: 0.000001245
Score: 0.169
Data Source: BioPlex,STRINGDB
SP3
Family: TF
Novelty: 0.00119924
p_int: 0.999900626
p_ni: 0.000099356
p_wrong: 1.8e-8
Score: 0.297
Data Source: BioPlex,STRINGDB
FAM241A
Novelty: 1.04041354
p_int: 0.998889199
p_ni: 0.001107327
p_wrong: 0.000003474
Score: 0.721
Data Source: BioPlex,STRINGDB
GNPTAB
Family: Enzyme
Novelty: 0.00336101
p_int: 0.99699528
p_ni: 0.00300472
Score: 0.157
Data Source: BioPlex,STRINGDB
HARS
Family: Enzyme
Novelty: 0.01271582
p_int: 0.971870221
p_ni: 0.028129779
Score: 0.534
Data Source: BioPlex,STRINGDB
SGCB
Novelty: 0.00970061
p_int: 0.971548086
p_ni: 0.028451914
Score: 0.955
Data Source: BioPlex,STRINGDB
ACACA
Family: Enzyme
Novelty: 0.00248313
p_int: 0.928173054
p_ni: 0.071826946
Score: 0.187
Data Source: BioPlex,STRINGDB
ATP5F1B
Family: Enzyme
Novelty: 0.01053177
p_int: 0.903942131
p_ni: 0.096057869
Data Source: BioPlex
ATP5PB
Family: Enzyme
Novelty: 0.07345384
p_int: 0.877662431
p_ni: 0.122337569
Data Source: BioPlex
REEP5
Novelty: 0.00160455
p_int: 0.800815448
p_ni: 0.199140176
p_wrong: 0.000044376
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 6 | 8 | 90.1 | |||||
intelligence | 4 | 6 | 2 | 6.6 | 77.9 | ||||
cognitive function measurement | 3 | 2 | 3 | 77.1 | |||||
body mass index | 3 | 2 | 3 | 76.7 | |||||
self reported educational attainment | 4 | 4 | 4 | 67.8 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 8 | 90.1 | |||||
intelligence | 2 | 6.6 | 77.9 | ||||
cognitive function measurement | 3 | 77.1 | |||||
body mass index | 3 | 76.7 | |||||
self reported educational attainment | 4 | 67.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sarcoglycan zeta | VGNC:14585 | 472703 | |||||
Macaque | sarcoglycan zeta | 100430474 | ||||||
Mouse | MGI:2388820 | 244431 | ||||||
Dog | sarcoglycan zeta | VGNC:49686 | 482890 | |||||
Opossum | sarcoglycan zeta | 100014044 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sarcoglycan zeta | |||||
Macaque | sarcoglycan zeta | |||||
Mouse | ||||||
Dog | sarcoglycan zeta | |||||
Opossum | sarcoglycan zeta | |||||
Publication Statistics
PubMed Score 12.91
PubMed score by year
PubTator Score 8.98
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
|---|