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Tbio
SGCB
Beta-sarcoglycan

Protein Summary
Description
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381431
  • ENSP00000370839
  • ENSG00000163069

Symbol
  • A3b
  • SGC
  • LGMD2E
  • LGMDR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.81
PubMedID
0.81
disease perturbation
0.79
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
SGCZ
Tbio
Novelty:  0.08511312
p_int:  0.971548086
p_ni:  0.028451914
Score:  0.955
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.91864748
p_ni:  0.08135252
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.90716107
p_ni:  0.09283893
Score:  0.181
Data Source:  BioPlex,STRINGDB
TMED6
Tdark
Novelty:  0.598611
p_int:  0.878271991
p_ni:  0.121728009
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.859138525
p_ni:  0.140861475
Data Source:  BioPlex
CD160
Tbio
Novelty:  0.01511748
p_int:  0.857853698
p_ni:  0.142146302
Data Source:  BioPlex
TSPAN17
Tdark
Novelty:  0.51639684
p_int:  0.833463502
p_ni:  0.166536498
Score:  0.171
Data Source:  BioPlex,STRINGDB
SGCA
Tbio
Novelty:  0.00442268
Score:  0.983
Data Source:  STRINGDB
DMD
Tclin
Novelty:  0.00025661
Score:  0.979
Data Source:  STRINGDB
SGCE
Tbio
Novelty:  0.00449577
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Dilated cardiomyopathy (DCM)
KEGG
Viral myocarditis
KEGG
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG
Hypertrophic cardiomyopathy (HCM)
Name
Explore in Pharos
Explore in Source
Dilated cardiomyopathy (DCM)
Viral myocarditis
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Hypertrophic cardiomyopathy (HCM)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
2
1
1
64.1
platelet count
1
1
1
41
mean platelet volume
1
1
1
36
age at menopause
2
1
2
10.9
hemoglobin A1 measurement
1
1
1
8.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
1
1
64.1
platelet count
1
41
mean platelet volume
1
36
age at menopause
2
10.9
hemoglobin A1 measurement
1
8.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan beta
VGNC:2000
461332
Mouse
MGI:1346523
24051
Rat
RGD:1594202
680229
Dog
sarcoglycan beta
VGNC:46092
611066
Horse
sarcoglycan beta
VGNC:22912
100060566
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan beta
Mouse
Rat
Dog
sarcoglycan beta
Horse
sarcoglycan beta
Publication Statistics
PubMed Score 109.48
PubMed score by year
PubTator Score 226.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title