Tbio SGCB Beta-sarcoglycan

Protein Summary

Description

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q16585
• B7Z635
• O00661
• Beta-SG

Gene Name

• SGCB

Ensembl ID

• ENST00000381431
• ENSP00000370839
• ENSG00000163069

Symbol

• A3b
• SGC
• LGMD2E
• LGMDR4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
kinase perturbation	0.81
PubMedID	0.81
disease perturbation	0.79
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.48   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.48   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0