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Tbio
SGCA
Alpha-sarcoglycan

Protein Summary
Description
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262018
  • ENSP00000262018
  • ENSG00000108823
  • ENST00000344627
  • ENSP00000345522

Symbol
  • ADL
  • DAG2
  • ADL
  • DAG2
  • 50DAG
  • DMDA2
  • LGMD2D
  • LGMDR3
  • SCARMD1
  • adhalin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.81
protein domain
0.73
cell type or tissue
0.66
cellular component
0.66
tissue sample
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.15   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.15   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.985082045
p_ni:  0.014917955
Score:  0.177
Data Source:  BioPlex,STRINGDB
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
p_int:  0.94980767
p_ni:  0.05019233
Score:  0.158
Data Source:  BioPlex,STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
p_int:  0.934755572
p_ni:  0.065243924
p_wrong:  5.03e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
PTPRU
Tbio
Family:  Enzyme
Novelty:  0.0090218
p_int:  0.909864635
p_ni:  0.090135365
Score:  0.295
Data Source:  BioPlex,STRINGDB
DAD1
Tbio
Family:  Enzyme
Novelty:  0.00653242
p_int:  0.826075498
p_ni:  0.173825401
p_wrong:  0.000099102
Score:  0.187
Data Source:  BioPlex,STRINGDB
LGR4
Tbio
Family:  GPCR
Novelty:  0.01180123
p_int:  0.822604125
p_ni:  0.177394832
p_wrong:  0.000001042
Score:  0.165
Data Source:  BioPlex,STRINGDB
GPR180
Tbio
Novelty:  0.03378902
p_int:  0.756351508
p_ni:  0.243648492
Score:  0.577
Data Source:  BioPlex,STRINGDB
SGCD
Tbio
Novelty:  0.00501907
Score:  0.985
Data Source:  STRINGDB
SGCB
Tbio
Novelty:  0.00970061
Score:  0.983
Data Source:  STRINGDB
DMD
Tclin
Novelty:  0.00025661
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Dilated cardiomyopathy (DCM)
KEGG
Viral myocarditis
KEGG
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG
Hypertrophic cardiomyopathy (HCM)
Name
Explore in Pharos
Explore in Source
Dilated cardiomyopathy (DCM)
Viral myocarditis
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Hypertrophic cardiomyopathy (HCM)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
9
97.3
cup-to-disc ratio measurement
2
2
2
57.2
1
1
1
31.4
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
97.3
cup-to-disc ratio measurement
2
57.2
1
31.4
mathematical ability
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan alpha
VGNC:9604
468403
Macaque
sarcoglycan alpha
704493
Mouse
MGI:894698
20391
Rat
RGD:1308062
303468
Dog
sarcoglycan alpha
VGNC:46091
609265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan alpha
Macaque
sarcoglycan alpha
Mouse
Rat
Dog
sarcoglycan alpha
Publication Statistics
PubMed Score 217.15
PubMed score by year
PubTator Score 290.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title