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Tbio
SFXN4
Sideroflexin-4

Protein Summary
Description
Potential iron transporter. This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355697
  • ENSP00000347924
  • ENSG00000183605

Symbol
  • BCRM1
  • BCRM1
  • COXPD18
  • SLC56A4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
disease perturbation
0.83
kinase perturbation
0.81
tissue sample
0.68
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
OPA3
Tbio
Novelty:  0.01508376
Score:  0.734
Data Source:  STRINGDB
TSFM
Tbio
Novelty:  0.00468811
Score:  0.726
Data Source:  STRINGDB
CISD2
Tbio
Novelty:  0.01665752
Score:  0.716
Data Source:  STRINGDB
CSDE1
Tbio
Family:  TF
Novelty:  0.02625299
Score:  0.7
Data Source:  STRINGDB
SPG7
Tbio
Family:  Enzyme
Novelty:  0.00463357
Score:  0.692
Data Source:  STRINGDB
MTPAP
Tbio
Family:  Enzyme
Novelty:  0.03447508
Score:  0.673
Data Source:  STRINGDB
PSME4
Tbio
Novelty:  0.01206213
Score:  0.647
Data Source:  STRINGDB
GNAL
Tbio
Novelty:  0.01757098
Score:  0.64
Data Source:  STRINGDB
MAPK8IP3
Tbio
Family:  Enzyme
Novelty:  0.01127812
Score:  0.615
Data Source:  STRINGDB
EBF2
Tbio
Family:  TF
Novelty:  0.00921566
Score:  0.59
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL17 measurement
1
1
1
86.5
mean platelet volume
3
1
3
85.4
platelet aggregation
1
1
1
82.8
3
1
1
1.1
70.2
platelet count
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL17 measurement
1
86.5
mean platelet volume
3
85.4
platelet aggregation
1
82.8
1
1.1
70.2
platelet count
1
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 4
VGNC:5726
466261
Macaque
sideroflexin 4
702765
Mouse
MGI:2137680
94281
Rat
RGD:1306088
361778
Dog
sideroflexin 4
VGNC:53011
477838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 4
Macaque
sideroflexin 4
Mouse
Rat
Dog
sideroflexin 4
Publication Statistics
PubMed Score 5.84
PubMed score by year
PubTator Score 1.10
PubTator score by year
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Related Publications
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PMID
Year
Title