Tbio SFXN4 Sideroflexin-4

Protein Summary

Description

Potential iron transporter. This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q6P4A7
• Q6WSU4
• Q86TD9

Gene Name

• SFXN4

Ensembl ID

• ENST00000355697
• ENSP00000347924
• ENSG00000183605

Symbol

• BCRM1
• BCRM1
• COXPD18
• SLC56A4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
disease perturbation	0.83
kinase perturbation	0.81
tissue sample	0.68
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sideroflexin-4

Protein / Transfer/carrier Protein / Sideroflexin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0