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Tdark
SFSWAP
Splicing factor, suppressor of white-apricot homolog

Protein Summary
Description
Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261674
  • ENSP00000261674
  • ENSG00000061936
  • ENST00000541286
  • ENSP00000437738

Symbol
  • SFRS8
  • SWAP
  • SWAP
  • SFRS8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
histone modification site profile
0.93
virus perturbation
0.92
transcription factor binding site profile
0.87
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.26   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.26   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.382
Data Source:  BioPlex,STRINGDB
CACNA2D3
Tbio
Family:  IC
Novelty:  0.05267262
p_int:  0.999923057
p_ni:  0.000076943
Data Source:  BioPlex
PAGE2B
Tdark
Novelty:  0.70952249
p_int:  0.999700879
p_ni:  0.000298869
p_wrong:  2.53e-7
Data Source:  BioPlex
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999264877
p_ni:  0.000735123
p_wrong:  1e-9
Data Source:  BioPlex
RBM17
Tbio
Novelty:  0.04840999
p_int:  0.999074751
p_ni:  0.000925248
Score:  0.352
Data Source:  BioPlex,STRINGDB
TBC1D32
Tbio
Novelty:  0.25744084
p_int:  0.998402108
p_ni:  0.000574014
p_wrong:  0.001023878
Data Source:  BioPlex
CAPN13
Tdark
Novelty:  0.27206398
p_int:  0.998345184
p_ni:  0.001654808
p_wrong:  7e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
CHERP
Tbio
Novelty:  0.06955626
p_int:  0.992368193
p_ni:  0.007631807
Score:  0.739
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.986481234
p_ni:  0.012660114
p_wrong:  0.000858652
Data Source:  BioPlex
GPATCH11
Tdark
Novelty:  0.86338046
p_int:  0.983514126
p_ni:  0.016480913
p_wrong:  0.00000496
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
57.1
self reported educational attainment
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
57.1
self reported educational attainment
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor SWAP
VGNC:10335
452374
Macaque
splicing factor SWAP
709551
Mouse
MGI:101760
231769
Rat
RGD:1305004
304431
Dog
splicing factor SWAP
VGNC:46084
477438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor SWAP
Macaque
splicing factor SWAP
Mouse
Rat
Dog
splicing factor SWAP
Publication Statistics
PubMed Score 4.26
PubMed score by year
PubTator Score 27.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title