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Tbio
SFRP4
Secreted frizzled-related protein 4

Protein Summary
Description
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000436072
  • ENSP00000410715
  • ENSG00000106483

Symbol
  • FRPHE
  • PYL
  • FRP-4
  • FRPHE
  • FRZB-2
  • sFRP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
protein domain
0.85
biological process
0.84
small molecule perturbation
0.76
biological term
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.32   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.32   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
PPP2R3A
Tbio
Family:  Enzyme
Novelty:  0.0350873
p_int:  0.999987156
p_ni:  8.27e-7
p_wrong:  0.000012017
Score:  0.211
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999408494
p_ni:  0.000591506
Data Source:  BioPlex
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.998859276
p_ni:  0.001140724
Score:  0.2
Data Source:  BioPlex,STRINGDB
DCAF16
Tdark
Novelty:  0.35666992
p_int:  0.99508622
p_ni:  0.0024704
p_wrong:  0.00244338
Score:  0.158
Data Source:  BioPlex,STRINGDB
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.99256608
p_ni:  0.007433919
Score:  0.197
Data Source:  BioPlex,STRINGDB
CALR
Tbio
Novelty:  0.0004479
p_int:  0.986165662
p_ni:  0.013834338
Score:  0.228
Data Source:  BioPlex,STRINGDB
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.942286216
p_ni:  0.057713784
Score:  0.187
Data Source:  BioPlex,STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
p_int:  0.927882478
p_ni:  0.072117323
p_wrong:  1.99e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
WNT7A
Tbio
Novelty:  0.00421662
Score:  0.918
Data Source:  STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.916
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
15
25
99.7
bone density
5
7
9
94.9
Dupuytren Contracture
2
2
0
1.9
94.6
body height
3
3
3
70.8
1
1
0
1.2
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
25
99.7
bone density
9
94.9
Dupuytren Contracture
0
1.9
94.6
body height
3
70.8
0
1.2
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secreted frizzled related protein 4
VGNC:9071
463356
Macaque
secreted frizzled related protein 4
574393
Mouse
MGI:892010
20379
Rat
RGD:621075
89803
Dog
secreted frizzled related protein 4
VGNC:46082
483258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secreted frizzled related protein 4
Macaque
secreted frizzled related protein 4
Mouse
Rat
Dog
secreted frizzled related protein 4
Publication Statistics
PubMed Score 634.32
PubMed score by year
PubTator Score 124.33
PubTator score by year
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Related Publications
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PMID
Year
Title