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Tbio
SFPQ
Splicing factor, proline- and glutamine-rich

Protein Summary
Description
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nucle ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357214
  • ENSP00000349748
  • ENSG00000116560

Symbol
  • PSF
  • PSF
  • POMP100
  • PPP1R140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
disease perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.28   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.28   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (229)
RBMXL1
Tdark
Novelty:  0.81422952
p_int:  0.999987701
p_ni:  0.000012299
Score:  0.549
Data Source:  BioPlex,STRINGDB
PSPC1
Tbio
Novelty:  0.01002246
p_int:  0.999976162
p_ni:  0.000023838
Score:  0.991
Data Source:  BioPlex,STRINGDB
NONO
Tbio
Novelty:  0.00501502
p_int:  0.999931729
p_ni:  0.000068271
Score:  0.999
Data Source:  BioPlex,STRINGDB
DIDO1
Tbio
Family:  Epigenetic
Novelty:  0.0492858
p_int:  0.999931434
p_ni:  0.000068566
Score:  0.421
Data Source:  BioPlex,STRINGDB
MMADHC
Tbio
Novelty:  0.02299238
p_int:  0.999918674
p_ni:  0.000081325
p_wrong:  1e-9
Data Source:  BioPlex
PRRC2A
Tbio
Novelty:  0.01493149
p_int:  0.99983284
p_ni:  0.000167151
p_wrong:  9e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
EWSR1
Tbio
Novelty:  0.00068411
p_int:  0.998663764
p_ni:  0.001336236
Score:  0.61
Data Source:  BioPlex,STRINGDB
LSM14A
Tbio
Novelty:  0.04728617
p_int:  0.993864477
p_ni:  0.006135523
Score:  0.244
Data Source:  BioPlex,STRINGDB
FAM98A
Tdark
Novelty:  0.30067413
p_int:  0.988658485
p_ni:  0.011341515
Score:  0.259
Data Source:  BioPlex,STRINGDB
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.985136351
p_ni:  0.014862906
p_wrong:  7.43e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
PTK6 Regulates Proteins Involved in RNA Processing (R-HSA-8849468)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 Regulates Proteins Involved in RNA Processing
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 Regulates Proteins Involved in RNA Processing
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
1
1
1
6.7
monocyte percentage of leukocytes
1
1
1
5.9
1
1
0
1.1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
1
6.7
monocyte percentage of leukocytes
1
5.9
0
1.1
1.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor proline and glutamine rich
VGNC:9516
469274
Macaque
splicing factor proline and glutamine rich
712439
Mouse
MGI:1918764
71514
Rat
RGD:727923
252855
Dog
splicing factor proline and glutamine rich
100688260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor proline and glutamine rich
Macaque
splicing factor proline and glutamine rich
Mouse
Rat
Dog
splicing factor proline and glutamine rich
Publication Statistics
PubMed Score 86.28
PubMed score by year
PubTator Score 119.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title