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Tbio
SF3B6
Splicing factor 3B subunit 6

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PubMed:16432215). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215). This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts dir ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233468
  • ENSP00000233468
  • ENSG00000115128

Symbol
  • SAP14
  • SF3B14
  • SF3B14A
  • P14
  • Ht006
  • SAP14
  • SAP14a
  • SF3B14
  • CGI-110
  • HSPC175
  • SF3B14a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
small molecule perturbation
0.81
histone modification site profile
0.77
transcription factor
0.7
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.07   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.07   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (260)
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.99379557
p_ni:  0.00620443
Score:  0.994
Data Source:  BioPlex,STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.977993402
p_ni:  0.022006598
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.949610418
p_ni:  0.050389582
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.867355641
p_ni:  0.132644359
Score:  0.98
Data Source:  BioPlex,STRINGDB
SF3B1
Tbio
Novelty:  0.0128965
Score:  0.999
Data Source:  STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.999
Data Source:  STRINGDB
SF3B5
Tdark
Novelty:  0.26636354
Score:  0.999
Data Source:  STRINGDB
SF3B3
Tchem
Novelty:  0.02866311
Score:  0.998
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.998
Data Source:  STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
4
13
94.6
reticulocyte measurement
3
5
8
90.7
lymphocyte count
3
3
4
88.1
HbA1c measurement
4
3
5
86.6
mean corpuscular volume
1
3
3
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
13
94.6
reticulocyte measurement
8
90.7
lymphocyte count
4
88.1
HbA1c measurement
5
86.6
mean corpuscular volume
3
86.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 6
VGNC:6398
459061
Macaque
splicing factor 3b subunit 6
704090
Mouse
MGI:1913305
66055
Dog
splicing factor 3b subunit 6
VGNC:46074
475682
Horse
splicing factor 3b subunit 6
VGNC:22893
100056247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 6
Macaque
splicing factor 3b subunit 6
Mouse
Dog
splicing factor 3b subunit 6
Horse
splicing factor 3b subunit 6
Publication Statistics
PubMed Score 12.07
PubMed score by year
PubTator Score 2.68
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title