You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SF3B5
Splicing factor 3B subunit 5

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367569
  • ENSP00000356541
  • ENSG00000169976

Symbol
  • SF3B10
  • Ysf3
  • SF3b10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
interacting protein
0.89
transcription factor binding site profile
0.89
disease perturbation
0.87
gene perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.930189993
p_ni:  0.069810007
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.905809109
p_ni:  0.094190882
p_wrong:  9e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.899723354
p_ni:  0.100276646
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.841818642
p_ni:  0.158181358
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.815158266
p_ni:  0.184841734
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.811159726
p_ni:  0.188840274
Score:  0.988
Data Source:  BioPlex,STRINGDB
LSM8
Tbio
Novelty:  0.08782322
Score:  0.999
Data Source:  STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
Score:  0.999
Data Source:  STRINGDB
SF3B4
Tbio
Novelty:  0.0197008
Score:  0.999
Data Source:  STRINGDB
SF3B6
Tbio
Novelty:  0.14923645
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
3
89.9
viral load
1
1
1
68.6
testosterone measurement
1
1
1
61
monocyte count
2
1
2
49.2
neutrophil percentage of leukocytes
2
1
2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
89.9
viral load
1
68.6
testosterone measurement
1
61
monocyte count
2
49.2
neutrophil percentage of leukocytes
2
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 5
VGNC:11245
748026
Mouse
MGI:1913375
66125
Rat
RGD:1586993
680891
Dog
splicing factor 3b subunit 5
VGNC:46073
100856528
Horse
splicing factor 3b subunit 5
VGNC:22892
100060669
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 5
Mouse
Rat
Dog
splicing factor 3b subunit 5
Horse
splicing factor 3b subunit 5
Publication Statistics
PubMed Score 3.27
PubMed score by year
PubTator Score 0.58
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title