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Tbio
SF3B2
Splicing factor 3B subunit 2

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322535
  • ENSP00000318861
  • ENSG00000087365

Symbol
  • SAP145
  • Cus1
  • SF3b1
  • SAP145
  • SF3B145
  • SF3b150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
ligand (protein) perturbation
0.96
co-expressed gene
0.93
hub protein
0.92
transcription factor perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.57   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.57   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (310)
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.99972076
p_ni:  0.00027924
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999581332
p_ni:  0.000418668
Score:  0.982
Data Source:  BioPlex,STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.994875427
p_ni:  0.005124573
Score:  0.77
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.992525179
p_ni:  0.007474821
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.991531791
p_ni:  0.008468209
Score:  0.995
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.98558644
p_ni:  0.01441356
Score:  0.985
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.977917777
p_ni:  0.022082223
Data Source:  BioPlex
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.960501924
p_ni:  0.039498076
Score:  0.949
Data Source:  BioPlex,STRINGDB
RBM17
Tbio
Novelty:  0.04840999
p_int:  0.946546201
p_ni:  0.053453799
Score:  0.96
Data Source:  BioPlex,STRINGDB
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.938599618
p_ni:  0.061400382
Score:  0.4
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
1
1
72.9
mathematical ability
2
2
2
70.4
C-reactive protein measurement
2
2
2
70.4
BMI-adjusted waist circumference
1
2
2
67.9
lifestyle measurement
1
1
1
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
72.9
mathematical ability
2
70.4
C-reactive protein measurement
2
70.4
BMI-adjusted waist circumference
2
67.9
lifestyle measurement
1
59.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 2
VGNC:3052
451343
Macaque
splicing factor 3B subunit 2
714747
Mouse
MGI:2441856
319322
Rat
RGD:1307159
293671
Dog
splicing factor 3b subunit 2
VGNC:46070
476015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 2
Macaque
splicing factor 3B subunit 2
Mouse
Rat
Dog
splicing factor 3b subunit 2
Publication Statistics
PubMed Score 44.57
PubMed score by year
PubTator Score 10.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title