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Tbio
SF3B1
Splicing factor 3B subunit 1

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335508
  • ENSP00000335321
  • ENSG00000115524
  • ENST00000409915
  • ENSP00000428820
  • ENST00000414963
  • ENSP00000402997

Symbol
  • SAP155
  • MDS
  • PRP10
  • Hsh155
  • PRPF10
  • SAP155
  • SF3b155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase perturbation
0.99
transcription factor perturbation
0.88
drug perturbation
0.87
protein complex
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.98   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.98   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (439)
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.99988672
p_ni:  0.00011328
Score:  0.983
Data Source:  BioPlex,STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.999613728
p_ni:  0.000386272
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.998990018
p_ni:  0.001009982
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.998226869
p_ni:  0.001773131
Score:  0.986
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.994863166
p_ni:  0.005136834
Data Source:  BioPlex
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.992645829
p_ni:  0.007354171
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.98966913
p_ni:  0.01033087
Score:  0.991
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.989279919
p_ni:  0.010720081
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.970042174
p_ni:  0.029957826
Score:  0.998
Data Source:  BioPlex,STRINGDB
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.958288655
p_ni:  0.041711345
Score:  0.968
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

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Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Positive epigenetic regulation of rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Metabolism of RNA
Positive epigenetic regulation of rRNA expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1
76.1
8
5
2
1.1
75.7
Eczema
1
1
0
1
57.3
1
1
0
1
57.3
1
2
0
1.1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
76.1
2
1.1
75.7
Eczema
0
1
57.3
0
1
57.3
0
1.1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 1
VGNC:2814
459850
Macaque
splicing factor 3b subunit 1
697773
Mouse
MGI:1932339
81898
Rat
RGD:620148
84486
Dog
splicing factor 3b subunit 1
VGNC:46069
488456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 1
Macaque
splicing factor 3b subunit 1
Mouse
Rat
Dog
splicing factor 3b subunit 1
Publication Statistics
PubMed Score 92.98
PubMed score by year
PubTator Score 222.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title